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A highly efficient and antifouling microfluidic platform for portable hemodialysis devices

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Abstract

End-stage renal disease (ESRD) is a life-threatening illness that presents significant healthcare challenges. About 90% of ESRD patients receive hemodialysis treatment, but the currently available hemodialysis systems are bulky and prone to complications. We report the design of a microfluidic hemodialysis device composed of two polydimethylsiloxane (PDMS) chambers separated by a cellulose ester (CE) membrane. The polyethylene glycol-passivated PDMS and CE surfaces reduced platelet adhesion by 74% and 86%, respectively. Moreover, the device exhibited a higher urea clearance rate per unit area than a healthy kidney. The reported design sets the foundation for a next-generation biomimetic portable hemodialysis device.

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Authors and Affiliations

  1. Department of Chemistry & Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada

    Irfani R. Ausri, Eliana M. Feygin, Connie Q. Cheng, Yuxing Wang, Zhi Yuan (William) Lin & Xiaowu (Shirley) Tang

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  1. Irfani R. Ausri
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  2. Eliana M. Feygin
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  3. Connie Q. Cheng
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  4. Yuxing Wang
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  5. Zhi Yuan (William) Lin
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  6. Xiaowu (Shirley) Tang
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Correspondence to Xiaowu (Shirley) Tang.

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Ausri, I.R., Feygin, E.M., Cheng, C.Q. et al. A highly efficient and antifouling microfluidic platform for portable hemodialysis devices. MRS Communications 8, 474–479 (2018). https://doi.org/10.1557/mrc.2018.43

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  • DOI: https://doi.org/10.1557/mrc.2018.43

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