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Investigation of the redox state of magnetite upon Aβ-fibril formation or proton irradiation; implication of iron redox inactivation and β-amyloidolysis

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Abstract

In in vitro separate compartment model of neuronal cells and extracellular iron oxide nanoparticles (IONs)—amyloid complexes, a traversing proton-induced Coulomb nanoradiator effect (CNR) was found to break up the ION—amyloid fibrils and to induce redox changes in the IONs. We found that the CNR effect caused the conversion of redox-active iron (II) into redox-inactive iron (III) as well as the disruption of the ION—amyloid fibrils without significantly damaging normal neuronal cells. Our observations suggest a non-invasive redox inactivation and β-amyloidolyis-based therapy of neurotoxic Aβ plaque involving a traversing proton Coulomb nanochelator that would not substantially impact normal neuronal cells.

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Acknowledgments

This work was performed with financial support from the National Research Foundation of Korea funded by the MinistryofEducation, Science and Technology(grantnumbers 2013M2B2B1075774 and 2015 M2A2A7A1045270).

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Authors and Affiliations

  1. Department of Biomedical Engineering & Radiology, School of Medicine, Catholic University of Daegu, Daegu, 42472, Korea

    Younshick Choi & Jong-Ki Kim

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  1. Younshick Choi
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Correspondence to Jong-Ki Kim.

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The supplementary material for this article can be found at {rs|https://doi.org/10.1557/mrc.2018.102|url|}

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Choi, Y., Kim, JK. Investigation of the redox state of magnetite upon Aβ-fibril formation or proton irradiation; implication of iron redox inactivation and β-amyloidolysis. MRS Communications 8, 955–960 (2018). https://doi.org/10.1557/mrc.2018.102

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