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Bioabsorbable bioadhesive hydrogel comprising poly(acrylic acid) and poly (vinylpyrrolidone) for adhesion barrier and hemostatic device

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Abstract

Poly(acrylic acid) (PAA) and poly(vinylpyrrolidone) (PVP) are both highly safe synthetic polymers approved as pharmaceutical excipients. When their aqueous solutions are mixed, insoluble rigid complex is precipitated. On the other hand, if the dried PAA film was immersed in aqueous PVP solution, swollen PAA/PVP soft hydrogel was obtained. Heated drying of the gel afforded a transparent water-swellable film. The swellable PAA/PVP complex film exhibited favorable properties in medical use. If the film was put on a bleeding site, it swelled, and stuck to a hemorrhaging spot, and efficiently arrested bleeding. It could also prevent the adhesion formation by injured intestines.

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References

  1. E.A. Hardean, S. Bantayehu, M.J. Ryan, M.A. David, L.S. Mark, and H.L. Jeffrey: A comprehensive review of topical hemostatic agents efficacy and recommendations for Use. Ann. Surg. 251, 217 (2010).

    Article  Google Scholar 

  2. Y. Tomizawa: Clinical benefits and risk analysis of topical hemostats: a review. J. Artif. Organs 8, 137 (2005).

    Article  Google Scholar 

  3. T. Liakakos, N. Thomakos, P.M. Fine, C. Dervenis, and R.L. Young: Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Dig. Surg. 18, 260 (2001).

    Article  CAS  Google Scholar 

  4. H. Seyednejad, M. Imani, T. Jamieson, and A.M. Seifalian: Topical haemostatic agents. Br. J. Surg. 95, 1197 (2008).

    Article  CAS  Google Scholar 

  5. M.M. Reijnen, J.F. Meis, V.A. Postma, and H. van Goor: Prevention of intra-abdominal abscesses and adhesions using a hyaluronic acid solution in a rat peritonitis model. Arch. Surg. 134, 997 (1999).

    Article  CAS  Google Scholar 

  6. Y. Liu, A. Skardal, X.Z. Shu, and G.D. Prestwich: Prevention of peritendinous adhesions using a hyaluronan-derived hydrogel film following partial-thickness flexor tendon injury. J. Orthop. Res. 26, 562 (2008).

    Article  Google Scholar 

  7. P.J. Klingler, N.R. Floch, M.H. Seelig, S.A. Branton, J.T. Wolfe, and P.P. Metzger: Seprafilm®-induced peritoneal inflammation: a previously unknown complication. Dis. Colon Rectum 42, 1639 (1999).

    Article  CAS  Google Scholar 

  8. J.W. Kuo: Practical Aspects of Hyaluronan Based Medical; Adhesion Prevention and Wound Healing. (CRC Press, Boca Raton, Florida, USA, 2005), p. 185.

    Book  Google Scholar 

  9. H. Park and J.R. Robinson: Mechanisms of mucoadhesion of poly(acrylic acid) hydrogels. Pharm. Res. 4, 457 (1987).

    Article  CAS  Google Scholar 

  10. H.S. Ch’Ng, H. Park, P. Kelly, and J.R. Robinson: Bioadhesive polymers as platforms for oral controlled drug delivery II: synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J. Pharm. Sci. 74, 399 (1985).

    Article  Google Scholar 

  11. C. Lau and Y. Mi: A study of blending and complexation of poly(acrylic acid)/poly(vinyl pyrrolidone). Polymer 43, 823 (2002).

    Article  CAS  Google Scholar 

  12. Y.T.F. Tan, K.K. Peh, and O. Al-Hanbali: Investigation of interpolymer complexation between Carbopol and various grades of polyvinylpyrrolidone and effects on adhesion strength and swelling properties. J. Pharm. Pharm. Sci. 4, 7 (2001).

    CAS  Google Scholar 

  13. F.B. Vasheghani, F.H. Rajabi, M.H. Ahmadi, and A. Gholehzadeh: Effect of ionic strength of the solution of some hydrogen—bonded interpolymer complexes on the stability and thermodynamic parameters. POLIMERY 54, 261 (2009).

    Article  Google Scholar 

  14. F.B. Vasheghani, F.H. Rajabi, M.H. Ahmadi, and N. Zenooz: Qualitative investigation on some H-bonded interpolymer complexes by determination of thermodynamic parameters. J. Mex. Chem. Soc. 56, 212 (2012).

    Google Scholar 

  15. M.J. Wahl: Dental surgery in anticoagulated patients, dental surgery in anticoagulated patients. Arch. Intern. Med. 158, 1610 (1998).

    Article  CAS  Google Scholar 

  16. A.B. Maulaz, D.C. Bezerra, P. Michel, and J. Bogousslavsky: Effect of discontinuing aspirin therapy on the risk of brain ischemic stroke. Arch. Neurol. 62, 1217 (2005).

    Article  Google Scholar 

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Acknowledgments

This work was partly supported by Izumi Science and Technology Foundation. Authors also thank CBC Co. Ltd., and BASF Japan Ltd. (Tokyo, Japan) for kindly giving PAA and PVP, respectively.

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Authors and Affiliations

  1. Japan Anti-tuberculosis Association, Shin-Yamanote Hospital, 3-6-1 Suwa-cho, Higashimurayama, Tokyo, 189-0021, Japan

    Tomoko Ito, Masazumi Eriguchi & Yoshiyuki Koyama

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  1. Tomoko Ito
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  2. Masazumi Eriguchi
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  3. Yoshiyuki Koyama
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Correspondence to Tomoko Ito.

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Ito, T., Eriguchi, M. & Koyama, Y. Bioabsorbable bioadhesive hydrogel comprising poly(acrylic acid) and poly (vinylpyrrolidone) for adhesion barrier and hemostatic device. MRS Communications 5, 291–295 (2015). https://doi.org/10.1557/mrc.2015.14

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  • DOI: https://doi.org/10.1557/mrc.2015.14

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