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Honey and curcumin loaded multilayered polyvinylalcohol/cellulose acetate electrospun nanofibrous mat for wound healing

  • Biomedical Materials, Regenerative Medicine and Drug Delivery
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Abstract

Bioactive dressings which can treat any kind of chronic or acute wounds and can fully replace the conventional gauzes and superabsorbent dressings have proven to be a future market of wound care products in recent times. These dressings are multifunctional, which can effectively combat the wound infection, remove the exudate, promote angiogenesis, and protect the wound from external trauma. Proper selection of bioactive and polymer defines its efficiency. Current research unveils the therapeutic efficacy of curcumin–honey-loaded multilayered polyvinyl alcohol/cellulose acetate electrospun nanofibrous mats as an interactive bioactive wound dressing material. Scanning electron microscopy and Fourier transform infrared spectroscopy analysis infers uniform encapsulation and chemical compatibility of herbal actives and polymer, inside the nanofibrous layers. The as-spun mat shows potential resistance towards Escherichia coli and ∼90% antioxidant activity against diphenyl-picrylhydrazyl (DPPH)–free radical. Additionally, water absorbency, water vapor transmission rate, and wettability analysis show quick and excellent absorption with controlled transmission of wound exudate.

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Acknowledgments

We acknowledge Dr. Mudrika Khandelwal for providing us the facility to carry out the antimicrobial testing. CSS acknowledges DST INSPIRE Faculty grant for partial financial support to carry out this work.

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Authors and Affiliations

  1. Creative and Advanced Research Based on Nanomaterials (CARBON) Laboratory, Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Telangana, 502285, India

    Mrunalini K. Gaydhane, Jaya S. Kanuganti & Chandra S. Sharma

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  1. Mrunalini K. Gaydhane
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  2. Jaya S. Kanuganti
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  3. Chandra S. Sharma
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Correspondence to Mrunalini K. Gaydhane.

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Gaydhane, M.K., Kanuganti, J.S. & Sharma, C.S. Honey and curcumin loaded multilayered polyvinylalcohol/cellulose acetate electrospun nanofibrous mat for wound healing. Journal of Materials Research 35, 600–609 (2020). https://doi.org/10.1557/jmr.2020.52

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