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Effect of anisotropic silk fibroin topographies on dorsal root ganglion

  • Biomedical Materials, Regenerative Medicine and Drug Delivery
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Abstract

The surface topology of biomaterial has a definite effect on the growth behavior of nerve cells for peripheral nerve regeneration. In this study, the silk fibroin (SF) film with different anisotropic microgroove/ridge was constructed by micropatterning technology. The effects of topologies width on the directional growth of dorsal root ganglion (DRG) neurons were evaluated. The results showed that the topological structure of the SF film with higher SF concentration was more clear and complete. The microtopography of the SF film with a concentration of 15% and a groove width of around 30 μm could effectively guide the directional growth of the nerve fibers of DRG. And nerve fibers could obviously form nerve fiber bundles which may have a certain pavement effect on the recovery of nerve function. The study indicated that the SF film with a specific width of the topological structure may have potential applications in the field of directional nerve regeneration.

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Acknowledgments

The authors gratefully acknowledge the financial support of the National Key Research and Development Program of China (2018YFC1105603, 2016YFC1101600), the National Natural Science Foundation of China (31830028, 31771054). Natural Key Science Research Program of Jiangsu Education Department (19KJA320006), Directive Project of Science and Technology Plan of Nantong City (MS12018028), 226 High-level Talent Training Project (2nd level, 2018 II-182) of Nantong City, Qinglan Project of Jiangsu Province (2018), Undergraduate Innovation Training Programs of Nantong University (2019119).

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Authors and Affiliations

  1. Key Laboratory of Eco-Textiles, Ministry of Education, School of Textiles and Clothing, Jiangnan University, 214122, Wuxi, Jiangsu, P.R. China

    Yan Kong & Yumin Yang

  2. Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, 226001, Nantong, P.R. China

    Liling Zhang, Qi Han, Shiyu Chen, Guicai Li & Yumin Yang

  3. Co-innovation Center of Neuroregeneration, Nantong University, 226001, Nantong, P.R. China

    Liling Zhang, Qi Han, Shiyu Chen, Guicai Li & Yumin Yang

  4. School of Medicine, Nantong University, 226001, Nantong, P.R. China

    Yifan Liu, Hanshuo Mu & Yiheng Liu

  5. Department of Ultrasound, Affiliated Hospital of Nantong University, 226001, Nantong, P.R. China

    Xiaoyang Chen

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  1. Yan Kong
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  2. Liling Zhang
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Correspondence to Guicai Li.

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Kong, Y., Zhang, L., Han, Q. et al. Effect of anisotropic silk fibroin topographies on dorsal root ganglion. Journal of Materials Research 35, 1738–1748 (2020). https://doi.org/10.1557/jmr.2020.131

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