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Fabrication of polyelectrolyte microspheres using porous manganese carbonate as sacrificial template for drug delivery application

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Abstract

This paper describes the fabrication of polyelectrolyte microspheres using porous manganese carbonate as a sacrificial template for entrapped photosensitizer (PS) drugs for photodynamic therapy application. These particles were used as templates for polyelectrolyte layer-by-layer assembly (Lbl) of two oppositely charged polyelectrolytes: poly(styrene sulfonate) and poly(allylamine hydrochloride). When the polyelectrolyte multilayer shell was built around the MnCO3 core by the Lbl protocol and the core was extracted with acid solution and EDTA, the resultant assembly consisted of hollow polyelectrolyte spheres. Chloroaluminum phthalocyanine was chosen as the model drug to load into the hollow spheres. All the spectroscopic results presented showed excellent photophysical parameters of the studied drug. The fabrication of polyelectrolyte hollow spheres can be used as an optimal medium for a variety of bioactive materials, which can also be encapsulated by the proposed method.

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Acknowledgments

The authors acknowledge the financial support of the Brazilian Agency CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) with the project number 800038/2014-2.

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Authors and Affiliations

  1. Organic Synthesis Laboratory, Research and Development Institute—IPD, Vale do Paraíba University, São José dos Campos, 12244-000, Brazil

    Alexandro da Silva Abreu, Janicy Arantes Carvalho, Milton Beltrame Junior & Andreza Ribeiro Simioni

  2. Departament of Chemistry, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine (CNET), University of São Paulo, Ribeirão Preto, SP, 14040-901, Brazil

    Antonio Claudio Tedesco

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  1. Alexandro da Silva Abreu
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  2. Janicy Arantes Carvalho
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Correspondence to Andreza Ribeiro Simioni.

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Abreu, A.d.S., Carvalho, J.A., Tedesco, A.C. et al. Fabrication of polyelectrolyte microspheres using porous manganese carbonate as sacrificial template for drug delivery application. Journal of Materials Research 34, 1353–1362 (2019). https://doi.org/10.1557/jmr.2019.47

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