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Luminogen-functionalized mesoporous SBA-15 for fluorescent detection of antibiotic cefalexin

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Abstract

A novel luminogen-functionalized SBA-15, denoted as SNT, was developed by incorporating tris(4-bromophenyl)amine (TBPA) into SBA-15 via a “fixation-induced emission” strategy. The emission of TBPA on the matrix of SBA-15 was greatly enhanced, making the SNT possible as a fluorescence sensor. Cefalexin, a typical antibiotic, was chosen as the model analyte to be assayed and sensitive detection performance was achieved. This is the first time for cefalexin to be detected by a fluorescent method. Moreover, the SNT can be recycled by simply washing with proper solvents then used for next detection. This work provides a strategy to greatly improve the emission characteristics of fluorophores, even if a mediocre small fluorophore. It can be extended to design practical fluorescent sensors with high performance and recyclability by this strategy.

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ACKNOWLEDGMENTS

This work was financially supported by the National Natural Science Foundation of China (21676070), Hebei Natural Science Foundation (B2015208109), Hebei Training Program for Talent Project (A201500117), Hebei One Hundred-Excellent Innovative Talent Program (III) (SLRC2017034), Hebei Science and Technology Project (17214304D), and the Excellent Going Abroad Experts’ Training Program in Hebei Province.

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Authors and Affiliations

  1. College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China

    Lei Liu, Xinyu Fu, Hongliang Zhang, Weiqing Ma, Lili Zhang, Yixin Zhang, Meng Liu, Kehan Liang & Aibing Chen

  2. The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050000, People’s Republic of China

    Senlin Hou

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  1. Lei Liu
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  2. Xinyu Fu
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  3. Hongliang Zhang
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  4. Weiqing Ma
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  5. Lili Zhang
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  7. Meng Liu
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Correspondence to Lei Liu, Senlin Hou or Aibing Chen.

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Liu, L., Fu, X., Zhang, H. et al. Luminogen-functionalized mesoporous SBA-15 for fluorescent detection of antibiotic cefalexin. Journal of Materials Research 33, 1442–1448 (2018). https://doi.org/10.1557/jmr.2018.96

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