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3D-printed β-TCP bone tissue engineering scaffolds: Effects of chemistry on in vivo biological properties in a rabbit tibia model

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Abstract

In this study, the effects of 3D-printed SiO2 and ZnO-doped tricalcium phosphate (TCP) scaffolds with interconnected pores were evaluated on the in vivo bone formation and healing properties of a rabbit tibial defect model. Pure and doped TCP scaffolds were fabricated by a ceramic powder-based 3D printing technique and implanted into critical sized rabbit tibial defects for up to 4 months. In vivo bone regeneration was evaluated using chronological radiological examination, histological evaluations, SEM micrographs, and fluorochrome labeling studies. Radiograph results showed that Si/Zn-doped samples had slower degradation kinetics than the pure TCP samples. 3D printing of TCP scaffolds improved bone formation. The addition of dopants in the TCP scaffolds improved osteogenic capabilities when compared to the pure scaffolds. In summary, our findings indicate that the addition of dopants to the TCP scaffolds enhanced bone formation and in turn leading to accelerated healing.

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ACKNOWLEDGMENTS

The authors would like to acknowledge financial support from the National Institutes of Health (Grant No. NIH-R01-AR-006361). The authors wish to acknowledge the help rendered by Dr. Solaiman Tarafder, Washington State University and Vice Chancellor, West Bengal University of Animal and Fishery Sciences, Kolkata, India, for their generous and kind support to this work.

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Authors and Affiliations

  1. Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, 700037, West Bengal, India

    Samit Kumar Nandi

  2. W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, 99164-2920, USA

    Gary Fielding, Dishary Banerjee, Amit Bandyopadhyay & Susmita Bose

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  1. Samit Kumar Nandi
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  2. Gary Fielding
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  3. Dishary Banerjee
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  4. Amit Bandyopadhyay
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  5. Susmita Bose
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Correspondence to Susmita Bose.

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This author was an editor of this journal during the review and decision stage. For the JMR policy on review and publication of manuscripts authored by editors, please refer to http://www.mrs.org/editor-manuscripts/.

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Nandi, S.K., Fielding, G., Banerjee, D. et al. 3D-printed β-TCP bone tissue engineering scaffolds: Effects of chemistry on in vivo biological properties in a rabbit tibia model. Journal of Materials Research 33, 1939–1947 (2018). https://doi.org/10.1557/jmr.2018.233

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