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Preparation of chitosan/safflower and ligusticum wallichii polysaccharides hydrogel for potential application in drug delivery and tissue engineering

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Abstract

Biological hydrogel is important in drug delivery system and tissue engineering. In this paper, we prepared a series of biological hydrogels with N, O-carboxymethyl chitosan (CS) and oxidized safflower and ligusticum wallichii polysaccharide-II (oxidized SLWP-II). Morphological analysis indicated the N, O-carboxymethyl CS/oxidized SLWP-II hydrogels (CSLHs) had porous interior structures, pore diameter ranged from tens to hundreds of micrometers. In vitro release test showed, with proportion of N, O-carboxymethyl CS to oxidized SLWP increasing from 1:1 to 1:3, cumulative release of bovine serum albumin decreased from 99 to 82%. In vitro cytotoxicity study showed that the developed hydrogels were not cytotoxic during one week of culturing with WI-38 cells, and they have a role in promoting cell proliferation. So the N, O-carboxymethyl CS/oxidized safflower and ligusticum wallichii polysaccharide-II hydrogels might have potential application in the drug delivery system and tissue engineering.

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ACKNOWLEDGMENT

This work was supported by the National Natural Science Foundation of China (No. 81260070).

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Authors and Affiliations

  1. School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou City, Gansu, 730050, China

    Xiuying Pu, Xiaoyue Li, Weijie Zhang, Xiaochun Wang, Haibing Li, Haowen Li & Wenjun Xu

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  1. Xiuying Pu
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  2. Xiaoyue Li
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  3. Weijie Zhang
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  4. Xiaochun Wang
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  6. Haowen Li
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  7. Wenjun Xu
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Correspondence to Weijie Zhang.

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Pu, X., Li, X., Zhang, W. et al. Preparation of chitosan/safflower and ligusticum wallichii polysaccharides hydrogel for potential application in drug delivery and tissue engineering. Journal of Materials Research 32, 2719–2727 (2017). https://doi.org/10.1557/jmr.2017.255

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