Skip to main content
SpringerLink
Log in

Biomimetic modification of the gliding surface of extrasynovial tendon

  • Article
  • Published:
Journal of Materials Research Aims and scope Submit manuscript

Abstract

Tendons may be classified as intrasynovial or extrasynovial based upon their anatomic location. We studied the physical properties of extrasynovial and intrasynovial tendons. Extrasynovial tendon has a rougher surface and higher friction than intrasynovial tendon. A number of carbodiimide derivatized biomaterials were developed to modify the irregular surface of an extrasynovial tendon to mimic the smooth surface of an intrasynovial tendon. We found that carbodiimide derivatized hyaluronic acid-gelatin (cd-HA-gelatin) chemically bonded to the extrasynovial tendon surface and optimally reduced gliding resistance in vitro. This biosynthetic, biomimetic modification of the extrasynovial tendon surface may prove to be a useful clinical product.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M.J. Cohen, L. Kaplan: Histology and ultrastructure of the human flexor tendon sheath. J. Hand Surg. Am. 12, 25 (1987).

    Article  CAS  Google Scholar 

  2. L.G. Jozsa, P. Kannus: Human Tendons: Anatomy, Physiology and Pathology (Human Kinetics, Champaign, IL, 1997).

    Google Scholar 

  3. P. Kannus: Structure of the tendon connective tissue. Scand. J. Med. Sci. Sports 10, 312 (2000).

    Article  CAS  Google Scholar 

  4. Y. Okuda, J.P. Gorski, K.N. An, P.C. Amadio: Biochemical, histological, and biomechanical analyses of canine tendon. J. Ortho. Res. 5, 60 (1987).

    Article  CAS  Google Scholar 

  5. J.G. Seiler III, R.H. Gelberman, C.S. Williams, S.L. Woo, G.R. Dickersin, R. Sofranko, C.R. Chu, A.E. Rosenberg: Autogenous flexor-tendon grafts. A biomechanical and morphological study in dogs. J. Bone Joint Surg. Am. 75, 1004 (1993).

    Article  Google Scholar 

  6. J.G. Seiler III, C.R. Chu, D. Amiel, S.L. Woo, R.H. Gelberman: The Marshall R. Urist Young Investigator Award. Autogenous flexor tendon grafts. Biologic mechanisms for incorporation. Clin. Orthop. 345, 239 (1997).

    Article  Google Scholar 

  7. S. Uchiyama, P.C. Amadio, J.H. Coert, L.J. Berglund, K.N. An: Gliding resistance of extrasynovial and intrasynovial tendons through the A2 pulley. J. Bone Joint Surg. 79, 219 (1997).

    Article  CAS  Google Scholar 

  8. T. Momose, P.C. Amadio, M.E. Zobitz, C.F. Zhao, K.N. An: Effect of paratenon and repetitive motion on the gliding resistance of tendon of extrasynovial origin. Clin. Anat. 15, 199 (2002).

    Article  Google Scholar 

  9. R.H. Gelberman, I. Seiler, A. Rosenberg, P.D.A Heyman, D. Amiel: Intercalary flexor tendon grafts: A morphological study of intrasynovial and extrasynovial donor tendons. Scand. J. Plast. Reconstr. Hand Surg. 26, 257 (1992).

    Article  CAS  Google Scholar 

  10. J.G. Seiler, S. Uchiyama, F. Ellis, P.C. Amadio, R.H. Gelberman, K.N. An: Reconstruction of the flexor pulley. The effect of the tension and source of the graft in an in vitro dog model. J. Bone Joint Surg. Am. 80, 699 (1998).

    Article  CAS  Google Scholar 

  11. K.N. An, L. Berglund, S. Uchiyama, J.H. Coert: Measurement of friction between pulley and flexor tendon. Biomed. Sci. Instrum. 29, 1 (1993).

    CAS  Google Scholar 

  12. Y.L. Sun, C. Yang, P.C. Amadio, C. Zhao, M.E. Zobitz, K.N. An: Reducing friction by chemically modifying the surface of extrasynovial tendon grafts. J. Orthop. Res. 22, 984 (2004).

    Article  CAS  Google Scholar 

  13. J. Kastelic, A. Galeski, E. Baer: The multicomposite structure of tendon. Connect. Tissue Res. 6, 11 (1978).

    Article  CAS  Google Scholar 

  14. J.H. Coert, S. Uchiyama, P.C. Amadio, L.J. Berglund, K.N. An: Flexor tendon-pulley interaction after tendon repair. A biomechanical study. J. Hand Surg. (Br.) 20, 573 (1995).

    Article  CAS  Google Scholar 

  15. C. Zhao, P.C. Amadio, T. Momose, P. Couvreur, M.E. Zobitz, K.N. An: The effect of suture technique on adhesion formation after flexor tendon repair for partial lacerations in a canine model. J. Trauma 51, 917 (2001).

    Article  CAS  Google Scholar 

  16. J.V. Staros, R.W. Wright, D.M. Swingle: Enhancement by N-hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactions. Anal. Biochem. 156, 220 (1986).

    Article  CAS  Google Scholar 

  17. A.G. Ogston, J.E. Stanier: The physiological function of hyaluronic acid in synovial fluid; Viscous, elastic and lubricant properties. J. Phys. E 119, 244 (1953).

    CAS  Google Scholar 

  18. S. Uchiyama, P.C. Amadio, J. Ishikawa, K.N. An: Boundary lubrication between the tendon and the pulley in the finger. J. Bone Joint Surg. Am. 79, 213 (1997).

    Article  CAS  Google Scholar 

  19. J.R.E Fraser, T.C. Laurent, U.B.G Laurent: Hyaluronan: Its nature, distribution, function and turnover. J. Intern. Med. 242, 27 (1997).

    Article  CAS  Google Scholar 

  20. G.D. Jay, K. Haberstroh, C.J. Cha: Comparison of the boundary-lubricating ability of bovine synovial fluid, lubricin, and Healon. J. Biomed. Mater. Res. 40, 414 (1998).

    Article  CAS  Google Scholar 

  21. S.G. Rees, J.R. Davies, D. Tudor, C.R. Flannery, C.E. Hughes, C.M. Dent, B. Caterson: Immunolocalization and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon. Matrix Biol. 21, 593 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Orthopedic Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic College of Medicine, Rochester, Minnesota, 55905, USA

    Yulong Sun, Chunfeng Zhao, Peter C. Amadio & Kai-Nan An

Authors
  1. Yulong Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chunfeng Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter C. Amadio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kai-Nan An
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peter C. Amadio.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sun, Y., Zhao, C., Amadio, P.C. et al. Biomimetic modification of the gliding surface of extrasynovial tendon. Journal of Materials Research 21, 2079–2083 (2006). https://doi.org/10.1557/jmr.2006.0253

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1557/jmr.2006.0253

Search

Navigation