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Biomolecule-derived Fluorescent Carbon Nanoparticle as Bioimaging Probe

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Abstract

Nanomaterials have broad application potential in biomedical and environmental science. Engineered nanomaterials are required to explore such potential. Among them carbon-based fluorescent nanoparticles offer promising alternative of conventionally used semiconductor nanocrystals, as they do not have heavy metals and associated toxicity issues. We are developing synthetic methods for high quality fluorescent carbon nanoparticle, suitable for biological staining and diagnostics. Here we focus on synthesis of fluorescent carbon nanoparticle from biomolecules, exploiting the conventionally used nucleation-growth conditions for synthesis of high quality nanocrystals such as quantum dot and metal oxides. We have shown that high quality fluorescent carbon nanoparticle can be synthesized from folic acid, riboflavin and lactose and they can be used as non-toxic bio-imaging probe.

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References

  1. S. N. Baker and G. A. Baker, Angew. Chem. Int. Ed., 49, 6726–6744 (2010).

    Article  CAS  Google Scholar 

  2. Z. L. Wu, Z. X. Liu and Y. H. Yuan, J. Mater. Chem. B, 5, 3794–3809 (2017).

    Article  CAS  Google Scholar 

  3. R. Wang, K.-Q. Lu, Z.-R. Tang and Y.-J. Xu, J. Mater. Chem. A, 5, 3717–3734 (2017).

    Article  CAS  Google Scholar 

  4. M. Righetto, A. Privitera, I. Fortunati, D. Mosconi, M. Zerbetto, M. L. Curri, M. Corricelli, A. Moretto, S. Agnoli, L. Franco, R. Bozio and C. Ferrante, J. Phys. Chem. Lett., 8, 2236–2242 (2017).

    Article  CAS  Google Scholar 

  5. A. Sharma, T. Gadly, S. Neogy, S. K. Ghosh and M. Kumbhakar, J. Phys. Chem. Lett., 8, 1044–1052 (2017).

    Article  CAS  Google Scholar 

  6. J. Schneider, C. J. Reckmeier, Y. Xiong, M. von Seckendorff, A. S. Susha, P. Kasak and A. L. Rogach, J. Phys. Chem. C, 121, 2014–2022 (2017).

    Article  CAS  Google Scholar 

  7. C. Wang, K. Jiang, Q. Wu, J. Wu and C. Zhang, Chem. Eur. J., 22, 14475–14479 (2016).

    Article  CAS  Google Scholar 

  8. H. Ding, S.-B. Yu, J.-S. Wei and H.-M. Xiong, ACS Nano, 10, 484–491 (2016).

    Article  CAS  Google Scholar 

  9. S. Sun, L. Zhang, K. Jiang, A. Wu and H. Lin, Chem. Mater., 28, 8659–8668 (2016).

    Article  CAS  Google Scholar 

  10. Z. Wang, F. Yuan, X. Li, Y. Li, H. Zhong, L. Fan and S. Yang, Adv. Mater., 29, 1702910 (2017).

    Article  Google Scholar 

  11. S. K. Bhunia, A. R. Maity, S. Nandi, D. Stepensky and R. Jelinek, ChemBioChem, 17, 614–619 (2016).

    Article  CAS  Google Scholar 

  12. F. Yang, G. E. LeCroy, P. Wang, W. Liang, J. Chen, K. A. S. Fernando, C. E. Bunker, H. Qian and Y.-P. Sun, J. Phys. Chem. C, 120, 25604–25611 (2016).

    Article  CAS  Google Scholar 

  13. J.-J. Hu, X.-L. Bai, Y.-M. Liu, X. Liao, Anal. Chim. Acta, 995, 99–105 (2017)

    Article  CAS  Google Scholar 

  14. L. Efremushkin, S. K. Bhunia, R. Jelinek, A. Salomon, J. Phys. Chem. Lett., 8, 6080–6085 (2017).

    Article  CAS  Google Scholar 

  15. N. R. Jana, PhysChemChemPhys, 13, 385–396 (2011).

    CAS  Google Scholar 

  16. S. K. Bhunia, A. Saha, A. R. Maity, S. C. Ray and N. R. Jana, Scientific Reports, 1473 (2013).

  17. S. K. Bhunia, N. Pradhan and Nikhil R. Jana, ACS Appl. Mater. Interfaces, 6, 7672–7679 (2014).

    Article  CAS  Google Scholar 

  18. H. Ali, S. K. Bhunia, C. Dalal and N. R. Jana, ACS Appl. Mater. Interfaces, 8, 9305–9313 (2016).

    Article  CAS  Google Scholar 

  19. Z. A. Peng and X. G. Peng, J. Am. Chem. Soc., 123, 183–184 (2001).

    Article  CAS  Google Scholar 

  20. N. R. Jana, Y. F. Chen and X. G. Peng, Chem. Mater., 16, 3931–3935 (2004).

    Article  CAS  Google Scholar 

  21. M. M. Tang and R. Bacon, Carbon, 2, 211–220 (1964).

    Article  CAS  Google Scholar 

  22. K. Lee, E. Park, H. A. Lee, C. Sugnaux, M. Shin, C. J. Jeong, J. Lee, P. B. Messersmith, S. Y. Park and H. Lee, Nanoscale, 9, 16596–16601 (2017).

    Article  CAS  Google Scholar 

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Correspondence to Nikhil R. Jana.

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Ali, H., Ghosh, S. & Jana, N.R. Biomolecule-derived Fluorescent Carbon Nanoparticle as Bioimaging Probe. MRS Advances 3, 779–788 (2018). https://doi.org/10.1557/adv.2018.80

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  • DOI: https://doi.org/10.1557/adv.2018.80

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