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Rheological Characterization of Alginate Based Hydrogels for Tissue Engineering

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Abstract

Hydrogels have been widely used in many applications from tissue engineering to drug delivery systems. For both tissue engineering and drug delivery, the mechanical properties are important because they would affect cell-materials interactions and injectability of drugs encapsulated in hydrogel carriers. Therefore, it is important to study the mechanical properties of these hydrogels, particularly at physiological temperature (37°C). This study adopted strain sweep and frequency sweep rotational rheological tests to investigate the rheological characteristics of various tissue engineering relevant hydrogels with different concentrations at 37°C. These hydrogels include alginate, RGD-alginate, and copolymerized collagen/alginate/fibrin. It has revealed that the addition of RGD has negligible effect on the elastic modulus and viscosity of alginate. Alginate gels have demonstrated shear thinning behavior which indicates that they are suitable candidates as carriers for cells or drug delivery. The addition of collagen and fibrin would reinforce the mechanical properties of alginate which makes it a strong scaffold material.

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Authors and Affiliations

  1. School of Mechanical and Systems Engineering, Newcastle University, Newcastle upon Tyne, UK

    Pengfei Duan, Nehir Kandemir, Jiajun Wang & Jinju Chen

  2. School of Chemical Engineering and Advanced Materials, Newcastle University, Newcastle upon Tyne, UK

    Pengfei Duan

Authors
  1. Pengfei Duan
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  2. Nehir Kandemir
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  3. Jiajun Wang
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  4. Jinju Chen
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Correspondence to Jinju Chen.

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These two authors contribute equally to this manuscript.

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Duan, P., Kandemir, N., Wang, J. et al. Rheological Characterization of Alginate Based Hydrogels for Tissue Engineering. MRS Advances 2, 1309–1314 (2017). https://doi.org/10.1557/adv.2017.8

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  • DOI: https://doi.org/10.1557/adv.2017.8

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