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Nanoimprinted SERS Sensors for Chemical and Biological Detection

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Abstract

Herein, we demonstrate a facile, rapid, and scalable method to fabricate polymer-based gratings for surface-enhanced Raman spectroscopy (SERS) sensors. To accomplish this, epoxy nanostripe arrays on silicon substrates were prepared using thermal annealing and UV-cross-linking. After preparation of the nanostripe arrays, the surface was briefly treated with oxygen plasma, which decreased the surface energy and enabled the growth of AgNPs on the polymer surface using a simple, low-cost, aqueous-based synthesis procedure. The SERS substrates exhibited a detection limit of ∼1 pM using rhodamine 6G (R6G). In addition, preliminary work with E. coli DH5 showed that the nanoimprinted substrates can be used to obtain Raman spectra of washed bacteria cells.

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Authors and Affiliations

  1. Bio-Science & Technology Team, Materials Science and Engineering Branch, US Army Natick Soldier RDEC, Natick, 01760, MA, USA

    Guinevere Strack, Michaela Fitzgerald & Ravi Mosurkal

  2. Department of Civil & Environmental Engineering, University of Massachusetts Lowell, Lowell, MA, 01854, USA

    Guinevere Strack, Michaela Fitzgerald & Pradeep Kurup

  3. Department of Mechanical Engineering, University of Massachusetts Lowell, Lowell, MA, 01854, USA

    Junwei Su & Hongwei Sun

  4. Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA, 01854, USA

    Margery G. H. Pelletier & Peter Gaines

Authors
  1. Guinevere Strack
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  2. Michaela Fitzgerald
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  3. Junwei Su
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  4. Margery G. H. Pelletier
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  5. Peter Gaines
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  6. Hongwei Sun
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  7. Pradeep Kurup
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  8. Ravi Mosurkal
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Corresponding authors

Correspondence to Pradeep Kurup or Ravi Mosurkal.

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Strack, G., Fitzgerald, M., Su, J. et al. Nanoimprinted SERS Sensors for Chemical and Biological Detection. MRS Advances 2, 1077–1082 (2017). https://doi.org/10.1557/adv.2017.44

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  • DOI: https://doi.org/10.1557/adv.2017.44

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