Abstract
Lipid-polymer hybrid nanoparticles (LPHN) have great potential as drug delivery devices for treatment of serious medical issues such as cardiovascular disease, tuberculosis, and cancer. Nanoprecipitation is a commonly used method to synthesize LPHN in a low cost manner. However, this multi-step process proves to be difficult in consistently producing uniformly sized nanoparticles. Here we developed a microfluidic device that utilizes a three-channel pathway and mixer channel to synthesize uniformly sized LPHN in a controlled manner. Dynamic light scattering results of the microfluidic synthesized nanoparticles show decrease in diameter size from 140 nm to 40 nm as the Reynolds number of the channel inflow increases. Transmission electron microscopy confirms the size and morphology of the nanoparticles. Three dimensional structure of the LPHN were observed using atomic force microscopy. The production of higher quality nanoparticles using our microfluidics device can expedite the research and development process of drug delivering lipid polymer nanoparticles.
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References
Q. Xu, S. Kambhampati, and R. Kannan. “Nanotechnology approaches for ocular drug delivery,” Middle East Afr J Ophthalmol, 20, 26–37 (2013).
J. Chan, L. Zhang, K. Yuet, G. Liao, J. Rhee, R. Langer, and O. Farokhzad, “PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery,” Biomaterials. 30, 1627–1634 (2009).
S. Mudshinge, A. Deore, S. Patil, and C. Saudi “Nanoparticles: Emerging carriers for drug delivery,” Pharmaceutical Journal, 10, 1016 (2011).
K. Raemdonck, K. Braeckmans, J. Demeester, S. De Smedt. “Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery,” Chemical Society Reviews, 10, 1039 (2014).
J. Chan, J. Rhee, C. Drum, R. Bronson, G. Golomb, R. Langer, O. Farokhzad, “In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid–polymeric nanoparticles,” Proceedings of the National Academy of Sciences, 10, 1073 (2011).
K. Hadinoto, A. Sundaresan, and W.Cheow, “Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review,” European journal of pharmaceutics and biopharmaceutics, 85, 427–43 (2013).
R. Fang, S. Aryal, C. Hu, and L. Zhang, “Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method,” Langmuir, 26, 16958–62 (2010).
L. Zhang, J.M. Chan, F.X. Gu, J. Rhee, A. Wang, A. Radovic-Moreno, F. Alexis, R. Langer, and O. Farokhzad, “Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform,” ACS nano. 2, 1696–702 (2008).
O. Farokhzad, A. Khademhosseini, S. Jon, A. Hermmann, J. Cheng, C. Chin, A. Kiselyuk, B. Teply, G. Eng, and R. Langer, “Microfluidic System for Studying the Interaction of Nanoparticles and Microparticles with Cells,” Analytical Chemistry. 77, 5453–5459 (2005).
Y. Kim, B. Chung, M. Ma, W. Mulder, Z. Fayad, O. Farokhzad, R. and Langer, “Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices,” Nano letters. 12, 3587–91 (2012).
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Takami, E.A., Erogbogbo, F. Microfluidic Synthesis of Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery. MRS Advances 1, 2155–2160 (2016). https://doi.org/10.1557/adv.2016.446
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DOI: https://doi.org/10.1557/adv.2016.446