Abstract
The development of biomaterials to treat, repair, or reconstruct the human body is an increasingly important component of materials research. Collaboration between materials researchers and their industrial and clinical partners is essential for the development of this complex field. To demonstrate the importance of these interactions, two articles in this issue focus on advances in biomaterials relating to the use of colloidal systems for transport, drug delivery, and other medical applications. These articles were coordinated by Dominique Muster (Université Louis Pasteur, Strasbourg) and Franz Burny (Hôpital Erasme, Brussels). The following is the second of these two articles.
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Additional information
Martin Garnett has been a lecturer in drug delivery within the Department of Pharmaceutical Sciences at the University of Nottingham since 1991. He graduated from the University College of Swansea (University of Wales) in 1974 with a BSc degree in biochemistry and then pursued postgraduate studies on biochemical aspects of chronic hyperoxia at University College London, earning his PhD degree in 1981. A change of field then followed with a postdoctoral position in the Cancer Research Campaign Laboratories at the University of Nottingham, where he worked on targeting drugs to cancer using monoclonal antibodies. Since his appointment as a lecturer in the Department of Pharmaceutical Sciences, he has expanded his interests over a wide range of drug delivery topics based on the use of polymers. These include polymerdrug conjugates, colloidal delivery systems, and DNA delivery systems using cationic polymers. In his work, particular emphasis has been placed on careful characterization of these systems and relating physicochemical properties of the delivery systems to their biological action.
Snjezana Stolnik graduated with a BSc degree from the Faculty of Pharmacy and Biochemistry at the University of Zagreb, Croatia. After a short period as a licensed pharmacist, she was appointed as a research and teaching assistant at the University of Zagreb, where she undertook master’s and PhD studies in the Fawlty of Pharmacy and Biochemistry. Partway through her PhD studies, she visited the Department of Pharmaceutical Sciences at the University of Nottingham and went on to complete her studies there, while qualifying with a PhD degree from the University of Zagreb. She was appointed first as a postdoctoral research assistant and then as AstraCharnwood lecturer in dmg delivery within the Department of Pharmaceutical Sciences at Nottingham. Her expertise and interests lie in the development of micro- and nanoparticulate carriers for drug delivery.
Susan Dunn, Ian Armstrong, and Wu Lin were all graduate students closely involved in the work described in this article. Both Susan Dunn and Ian Armstrong graduated from the University of Nottingham am with B. Pharm degrees in 1990. They undertook their postgraduate studies in the Department of Pharmaceutical Sciences at Nottingham in 1991 and eamed their PhD degrees in 1995. Wu Lin received a bachelor of pharmacy degree from Ahejiang Medical University, China, in 1982 and a master of science degree from Shanghai Medical University in 1988. He sta~ted his graduate studies at the Department of Pharmaceutical Sciences at Nottingham in 1993, earning his PhD degree in 1995.
Etienne Schacht is a professor in the Department of Organic Chemistry at the University of Ghent, Belgium. He is in charge of the Polymer Materials Research Group. Schacht is also research m1d development director for the Institute of Biomedical Technology (IBITECH) at U-Ghent. His research expertise is in polymers for biomedical applications.
Paolo Ferruti graduated in chemistry from tile University of Pavia, Collegia “Barromeo.” He then went to Milan Polytechnic at tile invitation of Giulio Natta, where he became assistm1t professor of industrial chemistry in 1965, associate professor of macromolecular chemistry in 1970, and full professor of macromolecular chemistry in 1975. He was appointed full professor of industrial chemistry at the University of Naples, also in 1975, where he remained !Illtil 1980, when he moved with tile same qualification to the University of Bologna. From 1983 to 1995, he was full professor of applied chemistry in the Faculty of Engineering at the University of Brescia. Since 1995, he has been full professor of macromolecular chemistry at tile University of Milan, Faculty of Sciences, Department of Organic mid Industrial Chemistry. Ferruti’s main scientific interest lies in synthesis and properties of multifunctional polymers. An important part of his activity is purpose-tailoring polymers for specific applications. He has authored or co-authored more than 200 papers. Ferruti can be reached at Dipertimento di Chimicn Organica e Industriale, Università degli Studi di Milano, Via Venezlan 21, 20133 Milano, Italy; tel. 39-2-70603222; fax 39-2-2364369; e-mail ferrut ip@imizzcca.csi.unimi.it.
Martyn Davies graduated with first-class honors in pharmacy and went on to earn a PhD degree in surface properties of film coatings with Professor Mike Newton at King’s College, University of London. After a brief spell at the University of Manchester, he was appointed lecturer in drug delivery at the University of Nottingham’s School of Pharmacy in 1986. Over the last 10 years or so, he has Jowsed his research activities on the application of advanced swjace analytical tools for the study of modern delivery systems. He co-founded the Laboratory of Biophysics and Surface Analysis within the University, which currently houses 22 researchers. In recognition of his research activities, Davies was promoted to a personal Chair in Biomedical Surface Chemistry in 1996.
Michel Vert was trained in polymer science at the University of Paris, where he graduated in 1963. ln 1965, he joined the CNRS as 11 junior scientist to prepare a DSc thesis, which was defended in 1969 at the University of Rauen. He was then promoted to senior scientist and became research director (research professor) in 1984. Vert is presently director of the ESA 5473 CNRS research unit, aimed at studying artificial biopolymers with a special attention to biodegradable polymers and polymers of thempeutic interest. He has authored more than 240 papers and filed 22 patents. He is editor of the Journal of Biomaterials Science: Polymer Edition.
Lisbeth Illum is the founder and managing director of DanBioSyst UK Ltd., a company specializing in drug delivery systems and presently employing 35 people. She is also associated with the University of Nottingham as a special professor. Size was awarded her M. Pharm, PhD, and DSc degrees from the Royal Danish School of Pharmacy in 1972, 1978, and 1988, respectively. Her rescarclz expertise is in the area of novel drug delivery systems for peptide and protein drugs, where size has studied the mechanisms of drug delivery using transmucosal routes. Her other research efforts center on the development of colloidal carrier systems for site-specific delivery of drugs, where she has established fzmdamental concepts in the field. Illum has published more tlza11 250 scientific papers and coedited Jour books, including Peptide Drug Delivery Systems, published by Plenum Press in 1986. Size has filed 30 patent applications on novel drug delivery systems. Size has been mvarded the title of “Docent” in the Royal Danish School of Pharmacy and has been the recipient of several awards, including the Marie Longgaards Award in 1988 for “outstanding scientific work” and the Amerslzam Award in 1987 for work on targeting to the bone marrow. She has been elected a Fellow of the American Association of Pharmaceutical Scientists (AAPS). She has lectured tlzrouglzout the world at conferences and workshops and serves on the editorial boards of tlze journals Drug Development and Industrial Pharmacy, Journal of Drug Targeting, International Journal of Pharmaceutics, and Pharmaceutical Research.
S.S. (Bob) Davis obtained his bachelor’s degree in pharmacy from the School of Pharmacy at the University of London in 1964. He remained at the same university to study for a PhD in colloid science, which he earned in 1967. In 1966, he was appointed assistant lecturer in pharmaceutics and promoted to lecturer in 1967. He moved his BSc degree in 1982. In 1968, Davis was awarded a one-year Fulbright scholarship to undertake postdoctoml studies with Takeru Higuchi at the University of Kansas in the field of solution thermodynamics. He moved to the University of Aston in Birmingham in 1970 as senior lecturer and head of the pharmaceutics section. Theere, he built up an active research group in drug delivery systems. Davis took up his present position at the University of Nottingham in 1975. He presently runs a large rescarch group, studying novel drug delivery systems. Topics of research include drug targeting (with particular emphasis on colloidal carriers), transmucosal delivery, and oral and parenteral systems for controlled release. He has published over 600 papers and is coeditor of seven books. He is chairman of two drug delivery companies, DanBioSyst UK Ltd. and Pharmaceutical Profiles Ltd.
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Garnett, M.C., Stolnik, S., Dunn, S.E. et al. Application of Novel Biomaterials in Colloidal Drug Delivery Systems. MRS Bulletin 24, 49–56 (1999). https://doi.org/10.1557/S0883769400052325
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DOI: https://doi.org/10.1557/S0883769400052325