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Development of Switchable “Smart” Biomaterials Using an Environmental Friendly Technology

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Abstract

The possibility of using three dimensional porous networks as microreactors for synthesizing thermoresponsive polymers and hydrogels in a CO2 environment is an important breakthrough in the strategies to prepare smart films, membranes and porous bulky devices that undergo fast reversible changes in surface properties triggered by external stimuli.In situ synthesis of thermoresponsive polymers namely, poly(N-isopropylacrylamide) (PNIPAAm) and poly (N,N-diethylacrylamide) (PDEAAm) within chitosan (CHT), collagen (CLG) and chitosan-collagen (CHT:CLG) blended scaffolds were performed in order to further impregnate with model drugs. The performance of these switchable release devices was evaluated through the study of drug release kinetics as a function of temperature and pH. The same methodology was successfully applied to produce thermoresponsive polysulfone-based membranes.

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Authors and Affiliations

  1. Requimte, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, 2829-516, Portugal

    Telma Barroso, Raquel Viveiros, Eunice Costa, Márcio Temtem, Teresa Casimiro & Ana Aguiar-Ricardo

Authors
  1. Telma Barroso
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  2. Raquel Viveiros
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  3. Eunice Costa
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  4. Márcio Temtem
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  5. Teresa Casimiro
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  6. Ana Aguiar-Ricardo
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Corresponding author

Correspondence to Ana Aguiar-Ricardo.

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Barroso, T., Viveiros, R., Costa, E. et al. Development of Switchable “Smart” Biomaterials Using an Environmental Friendly Technology. MRS Online Proceedings Library 1220, 2 (2009). https://doi.org/10.1557/PROC-1220-BB01-07

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  • DOI: https://doi.org/10.1557/PROC-1220-BB01-07

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