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Synthesis and characterization of multiphase bioactive glass-ceramics in the CaO–MgO–SiO2 system with B2O3 additive

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Abstract

A glass-ceramic (GC0) with nominal composition of 51.2% CaO–12.1% MgO–36.7% SiO2 (wt%) was synthesized. Then multiphase glass-ceramics of MGC1 and MGC2 were obtained by adding 1 and 2 wt% B2O3 to GC0 followed by thermal treatment. The bending strength of MGC1 was the highest, about 89.46 MPa, and the coefficient of thermal expansion was 10.67 × 10−6 °C−1, closer to that of Ti–6Al–4V alloy (10.03 × 10−6 °C−1). X-ray diffraction analysis confirmed that MGC1 was predominantly composed of akermanite, merwinite, and small amounts of dicalcium silicate crystalline phases. The bioactivity and cytocompatibility in vitro of MGC1 were detected by investigating the bonelike apatite-formation ability in simulated body fluid (SBF) and osteoblast morphology and viability. The results showed that MGC1 possessed bonelike apatite-formation ability in SBF and could release ionic products to significantly stimulate cell growth and viability. Furthermore, osteoblasts adhered and spread well on MGC1, indicating good bioactivity and potential cytocompatibility.

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Acknowledgments

Financial support from the Fund for Excellent Young Teachers of the Education Ministry of China (2002123) is gratefully acknowledged. We also thank Mengmeng Wang for her valuable assistance in the biological experiment and revising English grammar and syntax.

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Authors and Affiliations

  1. College of Materials Science and Engineering, Sichuan University, Chengdu, 610064, People’s Republic of China

    Xianchun Chen, Yan Wei, Zhongbing Huang, Yunqing Kang & Guangfu Yin

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  1. Xianchun Chen
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  2. Yan Wei
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  3. Zhongbing Huang
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  5. Guangfu Yin
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Correspondence to Guangfu Yin.

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Chen, X., Wei, Y., Huang, Z. et al. Synthesis and characterization of multiphase bioactive glass-ceramics in the CaO–MgO–SiO2 system with B2O3 additive. Journal of Materials Research 23, 2873–2879 (2008). https://doi.org/10.1557/JMR.2008.0376

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  • DOI: https://doi.org/10.1557/JMR.2008.0376

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