Journal of Flow Chemistry

, Volume 2, Issue 1, pp 5–7 | Cite as

Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols

  • Daniele De Zani
  • Matteo Colombo


O-Alkylation of phenol compounds was performed in a continuous flow apparatus under biphasic liquid/liquid conditions and promoted by tetrabutylammonium bromide (TBAB) as a phase-transfer catalyst. The segmented flow that is generated within the flow system is able to afford the desired ethers in high yield and in very short times.


alkylation ether flow chemistry phase-transfer catalysis phenol 

Supplementary material

41981_2012_2010005_MOESM1_ESM.pdf (147 kb)
Supplementary material, approximately 151 KB.


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Copyright information

© Akadémiai Kiadó 2012

Authors and Affiliations

  1. 1.NiKem ResearchMilanItaly

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