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Journal of Flow Chemistry

, Volume 1, Issue 2, pp 56–61 | Cite as

An Integrated Synthesis-Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery

  • Jill E. Hochlowski
  • Philip A. Searle
  • Noah P. Tu
  • Jeffrey Y. Pan
  • Stephen G. Spanton
  • Stevan W. Djuric
Full Paper

Abstract

We report herein a high-throughput integrated synthesis—purification platform termed SWIFT (synthesis with integrated-flow technology) and processes that accelerate the rate at which validated small-molecule organic compounds are generated. A segmented-flow synthesizer was integrated to a preparative HPLC-MS, where each reaction product was purified immediately upon reaction completion. Further, automated structure-validation processes accelerate the rate at which drug discovery candidates are available for biological screening.

Keywords

flow synthesis high-throughput organic synthesis high-throughput purification segmented flow meso-flow 

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Copyright information

© Akadémiai Kiadó 2011

Authors and Affiliations

  • Jill E. Hochlowski
    • 1
  • Philip A. Searle
    • 2
  • Noah P. Tu
    • 1
  • Jeffrey Y. Pan
    • 3
  • Stephen G. Spanton
    • 1
  • Stevan W. Djuric
    • 2
  1. 1.Structural Chemistry, Advanced Technology, Global Research and DevelopmentAbbott LaboratoriesAbbott ParkUSA
  2. 2.Medicinal Chemistry Technologies, Advanced Technology, Global Research and Development Abbott LaboratoriesAbbott ParkUSA
  3. 3.Automation Engineering, Advanced Technology, Global Research and DevelopmentAbbott LaboratoriesAbbott ParkUSA

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