Journal of Flow Chemistry

, Volume 5, Issue 3, pp 142–144 | Cite as

Efficient Continuous-Flow Synthesis of Macrocyclic Triazoles

  • Anne-Catherine Bédard
  • Jeffrey Santandrea
  • Shawn K. Collins


The continuous-flow synthesis of a series of 11- to 26-membered macrocycles via copper-catalyzed azide-alkyne cycloaddition is reported. The approach employs homogeneous catalysis to promote formation of triazole-containing macrocycles in good to excellent yields (65–90%) at relatively high concentration (30–50 mM) using a phase separation strategy.


macrocycle click copper 

Supplementary material

41981_2015_5030142_MOESM1_ESM.pdf (494 kb)
Supplementary material, approximately 506 KB.


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Copyright information

© Akadémiai Kiadó 2015

Authors and Affiliations

  • Anne-Catherine Bédard
    • 1
  • Jeffrey Santandrea
    • 1
  • Shawn K. Collins
    • 1
  1. 1.Department of Chemistry and Centre for Green Chemistry and CatalysisUniversité de MontréalMontréalCanada

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