Journal of Flow Chemistry

, Volume 4, Issue 2, pp 97–103 | Cite as

Highlights from the Flow Chemistry Literature 2014 (Part 1)

  • Toma N. Glasnov
Research Highlights


In this section of the journal, the continuous-flow chemistry literature of the preceding months is presented. Included are articles published in the period October–December 2013 and January–March 2014. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end.

Further Flow Chemistry Publications


  1. “Heating under high-frequency inductive conditions: application to the continuous synthesis of the neurolepticum olanzapine (Zyprexa)” J. Hartwig, S. Ceylan, L. Kupracz, L. Coutable, A. Kirschning Angewandte Chemie International Edition 2013, 52, 9813–9817CrossRefGoogle Scholar
  2. “Flow synthesis and biological studies of an analgesic adamantine derivative that inhibits P2X7-evoked glutamate release” C. Battilocchio, L. Guetzoyan, C. Cervetto, L. D. C. Mannelli, D. Frattaroli, I. R. Baxendale G. Maura, A. Rossi, L. Sautebin, M. Biava, C. Ghelardini, M. Marcoli, S. V. Ley* ACS Medicinal Chemistry Letters 2013, 4, 704–709CrossRefGoogle Scholar
  3. “A continuous flow solution to achieving efficient aerobic anti-Markovnikov Wacker oxidation” S. L. Bourne, S. V. Ley* Advanced Synthesis & Catalysis 2013, 355, 1905–1910CrossRefGoogle Scholar
  4. “Copper(I)/N-heterocyclic carbene (NHC)-catalyzed addition of terminal alkynes to trifluoromethyl ketones for use in continuous reactors” C. A. Correia, D. T. McQuade, P. H. Seeberger Advanced Synthesis & Catalysis 2013, 355, 3517–3521CrossRefGoogle Scholar
  5. “Continuous-flow Heck synthesis of 4-methoxybiphenyl and methyl 4-methoxycinnamate in supercritical carbon dioxide expanded solvent solutions” P. L. Lau, R. W. K. Allen, P. Styring* Beilstein Journal of Organic Chemistry 2013, 9, 2886–2897CrossRefGoogle Scholar
  6. “A microfluidic system for the continuous recycling of unmodified homogeneous palladium catalysts through liquid/liquid phase separation” P. Li, * J. S. Moore, K. F. Jensen* ChemCatChem 2013, 5, 1729–1733CrossRefGoogle Scholar
  7. “On-chip catalytic microreactors for modern catalysis research” -B. Xu, Y.-L. Zhang, * S. Wei, H. Ding, H.-B. Sun* ChemCatChem 2013, 5, 2091–2099CrossRefGoogle Scholar
  8. “Multistep continuous-flow synthesis in medicinal chemistry: discovery and preliminary structure-activity relationships of CCR8 ligands” T. P. Petersen, S. Mirsharghi, P. C. Rummel, S. Thiele, M. M. Rosenkilde, A. Ritzen, * T. Ulven* Chemistry European Journal 2013, 19, 9343–9350CrossRefGoogle Scholar
  9. “Two-phase enzymatic reaction using process intensification techniques” S. Elgue, * A. Conte, * A. Marty, J.-S. Condoret Chemistry Today 2013, 31(6), 43–47Google Scholar
  10. “Efficient terpene synthase catalysis by extraction in flow” O. Cascon, G. Richter, R. K. Allemann, * T. Wirth* ChemPlusChem 2013, 78, 1334–1337CrossRefGoogle Scholar
  11. “Hydrogen production through aqueous-phase reforming of ethylene glycol in a wash coated microchannel” M. F. N. D’Angelo, V. Ordomsky, V. Paunovic, J. van der Schaaf, J. C. Schouten, T. A. Nijhuis* ChemSusChem 2013, 6, 1708–1716CrossRefGoogle Scholar
  12. “Asymmetric anti-Mannich reactions in continuous flow” R. Martin-Rapun, S. Sayaleroa, M. A. Pericas Green Chemistry 2013, 15, 3295–3301CrossRefGoogle Scholar
  13. “Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant — a proof of principle study” M. Rudzinski, N. E. Leadbeater Green Processing & Synthesis 2013, 2, 323–328Google Scholar
  14. “Integrated lipase-catalyzed isoamyl acetate synthesis in a miniaturized system with enzyme and ionic liquid recycle” U. Novak, P. Znidarsic-Plazl* Green Processing & Synthesis 2013, 2, 561–568CrossRefGoogle Scholar
  15. “NADH oxidation in a microreactor catalysed by ADH immobilised on y-Fe2O3 nanoparticles” A. Salic, K. Pindric, G. H. Podrepsek, M. Leitgeb, * B. Zelic* Green Processing & Synthesis 2013, 2, 569–578CrossRefGoogle Scholar
  16. “A comparative study of ultrasound-, microwave-, and microreactor-assisted imidazolium-based ionic liquid synthesis” M. C. Bubalo, I. Sabotin, I. Rados, J. Valentincic, T. Bosiljkov, M. Brncic, P. Znidarsic-Plazl Green Processing & Synthesis 2013, 2, 579–590CrossRefGoogle Scholar
  17. “Improving energy efficiency of process of direct adipic acid synthesis in flow using pinch analysis” I. Vural-Gürsel, Q. Wang, T. Noël, V. Hessel, * J. T. Tinge Industrial & Engineering Chemistry Research 2013, 52, 7827–7835CrossRefGoogle Scholar
  18. “ADH based NAD* regeneration in a microreactor” A. Salic, M. Ivankovic, E. Ferk, B. Zelic* Journal of Chemical Technology & Biotechnology 2013, 88, 1721–1729CrossRefGoogle Scholar
  19. “Progress in computational microfluidics using TransAT” D. Lakehal, C. Narayanan, D. Caviezel, J. von Rickenbach, S. Reboux Microfluidics and Nanofluidics 2013, 15, 415–429CrossRefGoogle Scholar
  20. “Phase transfer catalyzed esterification: modeling and experimental studies in a microreactor under parallel flow conditions” E. Sinkovec, A. Pohar, M. Krajnc* Microfluidics and Nanofluidics 2013, 14, 489–498CrossRefGoogle Scholar
  21. “Application of continuous flow micromixing reactor technology for synthesis of benzimidazole drugs” G. S. Reddy, N. S. Reddy, K. Manudhane, M. V. R. Krishna, K. J. S. Ramachandra, S. Gangula* Organic Process Research & Development 2013, 17, 1272–1276CrossRefGoogle Scholar
  22. “Siloxane photopolymer to replace polydimethylsiloxane in microfluidic devices for polymerase chain reaction” A. Vitale, * M. Quaglio, S. Turri, M. Cocuzza, R. Bongiovani Polymers Advanced Technologies 2013, 24, 1068–1074CrossRefGoogle Scholar


  1. “Materials for Microfluidic Chip Fabrication” K. Ren, J. Zhou, H. Wu Accounts of Chemical Research 2013, 46, 2396–2406CrossRefGoogle Scholar
  2. “Asymmetric carbon-carbon bond formation under continuous-flow conditions with chiral heterogeneous catalysts” T. Tsubogo, T. Ishiwata, S. Kobayashi* Angewandte Chemie International Edition 2013, 52, 6590–6604CrossRefGoogle Scholar
  3. “Applications, benefits and challenges of flow chemistry” A. Mitic, S. Heintz, R. H. Ringborg, V. Bodla, J. M. Woodley, K. V. Gernaey* Chemistry Today 2013, 31, 4–8Google Scholar
  4. “Flow chemistry approaches directed at improving chemical synthesis” R. Baxendale, * L. Brocken, C. J. Mallia Green Processing & Synthesis 2013, 2, 211–230CrossRefGoogle Scholar
  5. “Multiphase biotransformations in microstructured reactors: opportunities for biocatalytic process intensification and smart flow processing” M. Bolivar, B. Nidetzky* Green Processing & Synthesis 2013, 2, 541–559CrossRefGoogle Scholar
  6. “Flow chemistry for designing sustainable chemical synthesis” R. Vaddula, M. A. Gonzalez Chemistry Today 2013, 31, 16–20Google Scholar
  7. “Continuous processes — sustainable manufacturing” J. Schrickel Chemistry Today 2013, 31, 22–25Google Scholar
  8. “Smart enzyme immobilization in microstructured reactors” J. M. Bolivar, B. Nidetzky Chemistry Today 2013, 31(3), 50–54Google Scholar
  9. “Accelerating photoredox catalysis in continuous microflow” T. Noel Chemistry Today 2013, 31(3), 10–14 (Monographic Supplement Series)Google Scholar


  1. ““Batch” kinetics in flow: online IR analysis and continuous control” J. S. Moore, K. F. Jensen* Angewandte Chemie International Edition 2014, 53, 470–473CrossRefGoogle Scholar
  2. “Combining on-chip synthesis of a focused combinatorial library with computational target prediction reveals imidazopyridine GPSR ligands” M. Reutlinger, T. Rodrigues, P. Schneider, G. Schneider* Angewandte Chemie International Edition 2014, 53, 582–585CrossRefGoogle Scholar
  3. “Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of ß-secretase (BACE1) inhibitors” M. Werner, C. Kuratli, R. E. Martin, R. Hochstrasser, D. Wechsler, T. Enderle, A. I. Alanine, H. Vogel Angewandte Chemie International Edition 2014, 53, 1704–1708CrossRefGoogle Scholar
  4. “High-rate continuous synthesis of nanocrystalline perovskites and metal oxides in a colliding vapor stream of microdroplets” T. Ould-Ely, L. Kaplan-Reinig, D. E. Morse * Advanced Functional Materials 2014, 24, 1275–1282CrossRefGoogle Scholar
  5. “One-step two-dimensional microfluidics-based synthesis of three-dimensional particles” N. Hakimi, S. S. H. Tsai, C.-H. Cheng, D. K. Hwang* Advanced Functional Materials 2014, 24, 1393–1398CrossRefGoogle Scholar
  6. “Synthesis of 3-arylated 3,4-dihydrocoumarins: combining continuous flow hydrogenation with laccase-catalysed oxidation” S. Suljic, J. Pietruszka, * Advanced Synthesis & Catalysis 2014, 356, 1007–1020CrossRefGoogle Scholar
  7. “Preparation of reusable bioreactors using reversible immobilization of enzyme on monolithic porous polymer support with attached gold nanoparticles” Y. Lv, Z. Lin, T. Tan, F. Svec* Biotechnology & Bioengineering 2014, 111, 50–58CrossRefGoogle Scholar
  8. “Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide” R. J. Ingham, C. Battilocchio, J. M. Hawkins, S. V. Ley* Beilstein Journal of Organic Chemistry 2014, 10, 641–652CrossRefGoogle Scholar
  9. “Robust and reusable supported palladium catalysts for cross-coupling reactions in flow” W. R. Reynolds, P. Plucinski, C. G. Frost* Catalysis Science & Technology 2014, 4, 948–954CrossRefGoogle Scholar
  10. “Heterogenized gold(I)-carbene as a single-site catalyst in continuous flow” C. Lothschtz, J. Szlachetko, J. A. van Bokhoven* ChemCatChem 2014, 6, 443–448CrossRefGoogle Scholar
  11. “Reusable supported ruthenium catalysts for the alkylation of amines by using primary alcohols” S. P. Shan, T. T. Dang, A. M. Seayad, B. Ramalingam* ChemCatChem 2014, 6, 808–814CrossRefGoogle Scholar
  12. “Electrochemical conversion of dichloroacetic acid to chloroacetic acid in conventional cell and in two microfluidic reactors” O. Scialdone, A. Galia, S. Sabatino, G. M. Vaiana, D. Agro, A. Busacca, C. Amatore ChemElectroChem 2014, 1, 116–124CrossRefGoogle Scholar
  13. “Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor” J. A. Newby, L. Huck, D. W. Blaylock, P. M. Witt, S. V. Ley, D. L. Browne* Chemistry A European Journal 2014, 30, 263–271CrossRefGoogle Scholar
  14. “Enantioselective continuous-flow production of 3-indolylmethanamines mediated by an immobilized phosphoric acid catalyst” L. Osorio-Planes, C. Rodriguez-Escrich, M. A. Pericas* Chemistry A European Journal 2014, 30, 2367–2372CrossRefGoogle Scholar
  15. “Biocompatible macro-initiators controlling radical retention in microfluidic on-chip photopolymerization of water-in-oil emulsions” Y. Ma, J. Thiele, L. Abdelmohsen, J. Xu, W. T. S. Huck* Chemical Communications 2014, 50, 112–114CrossRefGoogle Scholar
  16. “Selective monomethylation of primary amines with simple electrophiles” T. Lebleu, X. Ma, J. Maddaluno, J. Legros* Chemical Communications 2014, 50, 1836–1838CrossRefGoogle Scholar
  17. “Controlling size, crystallinity, and electrochemical performance of Li4Ti5O2 nanocrystals” Y. Shen, J. R. Eltzholtz, B. B. Iversen* Chemistry of Materials 2014, 25, 5023–5030CrossRefGoogle Scholar
  18. “Mechanism-guided design of flow systems for multicomponent reactions: conversion of CO2 and olefins to cyclic carbonates” J. Wu, J. A. Kozak, F. Simeon, T. A. Hatton, * T. F. Jamison* Chemical Science 2014, 5, 1227–1231CrossRefGoogle Scholar
  19. “Catalytic transfer hydrogenation/hydrogenolysis for reductive upgrading of furfural and 5-(hydroxymethyl)furfural” S. Scholz, C. Aellig, I. Hermans* ChemSusChem 2014, 7, 268–275CrossRefGoogle Scholar
  20. “Tube-in-tube reactor as a useful tool for homo- and heterogeneous olefin metathesis under continuous flow mode” K. Skowerski, S. J. Czarnocki, P. Knapkiewicz ChemSusChem 2014, 7, 536–542CrossRefGoogle Scholar
  21. “Microfluidic platform for continuous flow synthesis of triangular gold nanoplates” D. V. R. Kumar, A. A. Kulkarni, * B. L. V. Prasad* Colloids and Surfaces A: Physicochemical and Engineering Aspects 2014, 443, 149–155CrossRefGoogle Scholar
  22. “Glucose-6-phosphate dehydrogenase encapsulated in silica-based hydrogels for operation in a microreactor” S. Cumana, I. Ardao, A.-P. Zeng, I. Smirnova Engineering in Life Sciences 2014, 14, 170–179CrossRefGoogle Scholar
  23. “A continuous process for glyoxal valorisation using tailored Lewis-acid zeolite catalysts” P. Y. Dapsens, C. Mondelli, * B. T. Kusema, R. Verel, J. Perez-Ramirez* Green Chemistry 2014, 16, 1176–1186CrossRefGoogle Scholar
  24. “Supported ionic liquid-like phases as organocatalysts for the solvent-free cyanosilylation of carbonyl compounds: from batch to continuous flow process” S. Martin, R. Porcar, E. Peris, M. I. Burguete, E. Garcia-Verdugo, * S. V. Luis* Green Chemistry 2014, 16, 1639–1647CrossRefGoogle Scholar
  25. “Olefin autoxidation in flow” U. Neuenschwander, K. F. Jensen* Industrial & Engineering Chemistry Research 2014, 53, 601–608CrossRefGoogle Scholar
  26. “Photocatalytic hydrodefluorination: facile access to partially fluorinated aromatics” S. M. Senaweera, A. Singh, J. D. Weaver* Journal of the American Chemical Society 2014, 136, 3002–3005CrossRefGoogle Scholar
  27. “Continuous enzymatic carboligation of benzaldehyde and acetaldehyde in an enzyme ultrafiltration membrane reactor and laminar flow microreactors” D. Valingera, * A. V. Presecki, Z. Kurtanjek, M. Pohl, Z. F. Blazevic, D. Vasic-Racki Journal of Molecular Catalysis B: Enzymatic 2014, 102, 132–137CrossRefGoogle Scholar
  28. “Decarboxylative trichloromethylation of aromatic aldehydes and its applications in continuous flow” A. B. Jensen, A. T. Lindhardt* Journal of Organic Chemistry 2014, 79, 1174–1183CrossRefGoogle Scholar
  29. “Continuous flow synthesis of a-halo ketones: essential building blocks of antiretroviral agents” D. Pinho, B. Gutmann, L. S. M. Miranda, R. O. M. A. deSouza, C. O. Kappe* Journal of Organic Chemistry 2014, 79, 1555–1562CrossRefGoogle Scholar
  30. “Comparison of flow and batch polymerization processes for production of vinyl ether terpolymers for use in the delivery of siRNA” J. L. Nyrop, A. Soheili, R. Xiang, F. Meng, J. H. Waldman, X. Jia, R. G. Parmar, B. W. Thuronyi, J. M. Williams, L. Di Michele, M. Journet, B. J. Howell, B. Mao, I. W. Davies, S. L. Colletti, L. Sepp-Lorenzino, E. N. Guidry* Journal of Polymer Science Part A: Polymer Chemistry 2014, 52, 1119–1129CrossRefGoogle Scholar
  31. “High throughput synthesis of uniform biocompatible polymerbeads with high quantum dot loading using microfluidic jet-mode breakup” S.-K. Lee, J. Baek, K. F. Jensen* Langmuir 2014, 30, 2216–2222CrossRefGoogle Scholar
  32. “Scaled-up production of plasmonic nanoparticles using microfluidics: from metal precursors to functionalized and sterilized nanoparticles” L. Gomez, V. Sebastian, * S. Irusta, A. Ibarra, M. Arruebo, J. Santamaria* Lab on a Chip 2014, 14, 325–332CrossRefGoogle Scholar
  33. “Whole ceramic-like microreactors from inorganic polymers for high temperature or/and high pressure chemical syntheses” W. Ren, J. Perumal, J. Wang, H. Wang, S. Sharmac, D.-P. Kim Lab on a Chip 2014, 14, 779–786CrossRefGoogle Scholar
  34. “Continuous synthesis of zinc oxide nanoparticles in a microfluidic system for photovoltaic application” H. W. Kang, J. Leem, S. Y. Yoon, H. J. Sung* Nanoscale 2014, 6, 2840–2846CrossRefGoogle Scholar
  35. “Continuous flow a-trifluoromethylation of ketones by metal-free visible light photoredox catalysis” D. Cantillo, O. de Frutos, J. A. Rincoon, C. Mateos, C. O. Kappe Organic Letters 2014, 16, 896–899CrossRefGoogle Scholar
  36. “Continuous photochemical cleavage of linkers for solid-phase synthesis” M. Hurevich, J. Kandasamy, B. M. Ponnappa, M. Collot, D. Kopetzki, D. T. McQuade, P. H. Seeberger* Organic Letters 2014, 16, 1794–1797CrossRefGoogle Scholar
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  38. “Photo-induced copper-mediated polymerization of methyl acrylate in continuous flow reactors” B. Wenn, M. Conradi, A. D. Carreiras, D. M. Haddleton, T. Junkers* Polymer Chemistry 2014, 5, 3053–3060CrossRefGoogle Scholar
  39. “Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa- bicyclio[2.2.1]heptanes” L. Hizartzidis, M. Tarleton, C. P. Gordon, A. McCluskey* RSC Advances 2014, 4, 9709–9722CrossRefGoogle Scholar
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  41. “Two-step continuous-flow synthesis of CuInSe2 nanoparticles in a solar microreactor” P. B. Kreider, K.-J. Kim, C.-H. Chang* RSC Advances 2014, 4, 13827–13830CrossRefGoogle Scholar
  42. “Nonenzymatic sugar production from biomass using biomass-derived y-valerolactone” J. S. Luterbacher, J. M. Rand, D. M. Alonso, J. Han, J. T. Youngquist, C. T. Maravelias, B. F. Pfleger, J. A. Dumesic* Science 2014, 343, 277–280CrossRefGoogle Scholar
  43. “Safe generation and direct use of diazoesters in flow chemistry” S. T. R. Müller, D. Smith, P. Hellier, T. Wirth* Synlett 2014, 25, 871–875CrossRefGoogle Scholar


  1. “Continuous flow nitration in miniaturized devices” A. A. Kulkarni Beilstein Journal of Organic Chemistry 2014, 10, 405–424CrossRefGoogle Scholar
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  3. “Microfluidic platforms: a mainstream technology for the preparation of crystals” J. Puigmarti-Luis* Chemical Society Reviews 2014, 43, 2253–2271CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó 2014

Authors and Affiliations

  1. 1.Institute of ChemistryKarl-Franzens-University GrazGrazAustria

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