Abstract
After a short section of safety aspects related to 2-nitroethanol, the paper describes a powerful methodology for developing flow processes based on a proof of concept (1), an optimization and modeling analysis (2), and a long run study in a mini-plant (3). The proof of concept is the initial stage where the solubilities and concentrations are fixed, taking into account the rough kinetics with a mass transfer understanding. It is followed by a complete kinetic analysis including activation energy to model the reaction under various conditions to optimize different targets (yield not being the only driver!). The last section shows the operation of a mini-plant including a microreactor and work-up unit operations. The approach is extremely powerful as it enables the study at laboratory scale of all the features that are usually associated with a pilot plant namely: stability over time on stream, solvent recirculation, model prediction, and robustness.
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Roberge, D.M., Noti, C., Irle, E. et al. Control of Hazardous Processes in Flow: Synthesis of 2-Nitroethanol. J Flow Chem 4, 26–34 (2014). https://doi.org/10.1556/JFC-D-13-00016
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DOI: https://doi.org/10.1556/JFC-D-13-00016