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Journal of Flow Chemistry

, Volume 3, Issue 3, pp 66–75 | Cite as

Engineering Polymer Microparticles by Droplet Microfluidics

  • Christophe A. Serra
  • Ikram U. Khan
  • ZhenQi Chang
  • Michel Bouquey
  • René Muller
  • Isabelle Kraus
  • Marc Schmutz
  • Thierry Vandamme
  • Nicolas Anton
  • Christian Ohm
  • Rudolf Zentel
  • Andrea Knauer
  • Michael Köhler
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Abstract

Capillary-based flow-focusing and co-flow microsystems were developed to produce sphere-like polymer micro-particles of adjustable sizes in the range of 50 to 600 μm with a narrow size distribution (CV < 5%) and different morphologies (core–shell, janus, and capsules). Rod-like particles whose length was conveniently adjusted between 400 μm and few millimeters were also produced using the same microsystems. Influence of operating conditions (flow rate of the different fluid, microsystem characteristic dimensions, and design) as well as material parameters (viscosity of the different fluids and surface tension) was investigated. Empirical relationships were thus derived from experimental data to predict the microparticle’s overall size, shell thickness, or rods length. Besides morphology, microparticles with various compositions were synthesized and their potential applications highlighted: drug-loaded microparticles for new drug delivery strategies, composed inorganic–organic multiscale microparticles for sensorics, and liquid crystalline elastomer microparticles showing an anisotropic reversible shape change upon temperature for thermal actuators or artificial muscles.

Keywords

core-shell capsule janus rod thermal actuator composite particles drug microcarrier 

References

  1. 1.
    Christopher, G.F.; Anna, S.L. J. Phys. D: Appl. Phys. 2007, 40, R319–R336.CrossRefGoogle Scholar
  2. 2.
    Serra, C. Handbookof Micro Process Engineering, Wiley-VCH: Weinheim, 2009.Google Scholar
  3. 3.
    Serra, C. A.; Chang, Z. Chem. Eng. Technol. 2008, 31 (8), 1099–1115.CrossRefGoogle Scholar
  4. 4.
    Hessel, V.; Serra, C.; Löwe, H.; Hadziioannou, G. Chem. Ing. Tech. 2005, 77, 1693–1714.CrossRefGoogle Scholar
  5. 5.
    Steinbacher, J. L.; McQuade, D. T. J. Polym. Sci., Part A: Polym. Chem. 2006, 44, 6505–6533.CrossRefGoogle Scholar
  6. 6.
    Malloggi, F.; Pannacci, N.; Attia, R.; Monti, F.; Mary, P.; Willaime, H.; Tabeling, P.; Cabane, B.; Poncet, P. Langmuir 2010, 26 (4), 2369.CrossRefGoogle Scholar
  7. 7.
    Hennequin, Y.; Pannacci, N.; Pulido de Torres, C.; Tetradis-Meris, G.; Chapuliot, S.; Bouchaud, E.; Tabeling, P. Langmuir 2009, 25 (14), 7857–7861.CrossRefGoogle Scholar
  8. 8.
    Tabeling, P. Phys. Fluids 2010, 22, 21302.CrossRefGoogle Scholar
  9. 9.
    Nie, Z.; Li, W.; Seo, M.; Xu, S.; Kumacheva, E. J. Am. Chem. Soc. 2006, 128, 9408–9412.CrossRefGoogle Scholar
  10. 10.
    Nisisako, T.; Torii, T.; Higuchi, T. Chem. Eng. J. 2004, 101, 23–29.CrossRefGoogle Scholar
  11. 11.
    Nisisako, T.; Torii, T.; Takahashi, T.; Takizawa, Y. Adv. Mater. 2006, 18, 1152–1156.CrossRefGoogle Scholar
  12. 12.
    Shepherd, R. F.; Conrad, J. C.; Rhodes, S. K.; Link, D. R.; Marquez, M.; Weitz, D. A.; Lewis, J. A. Langmuir 2006, 22, 8618–8622.CrossRefGoogle Scholar
  13. 13.
    Kim, J. W.; Utada, A. S.; Fernández-Nieves, A.; Hu, Z.; Weitz, D. A. Angew. Chem., Int. Ed. 2007, 46 1819–1822.CrossRefGoogle Scholar
  14. 14.
    Xu, S. Q.; Nie, Z.; Seo, M.; Lewis, P.; Kumacheva, E.; Stone, H. A.; Garstecki, P.; Weibel, D. B.; Gitlin, I.; Whitesides, G. M. Angew. Chem., Int. Ed. 2005, 44, 724–728.CrossRefGoogle Scholar
  15. 15.
    Lewis, P. C.; Graham, R. R.; Nie, Z.; Xu, S.; Seo, M.; Kumacheva, E. Macrolecules 2005, 38, 4536–4538.CrossRefGoogle Scholar
  16. 16.
    Dendukuri, D.; Tsoi, K.; Hatton, T. A.; Doyle, P. S. Langmuir 2005, 21, 2113–2116.CrossRefGoogle Scholar
  17. 17.
    Seo, M.; Nie, Z.; Xu, S.; Lewis, P. C.; Kumacheva, E. Langmuir 2005, 21, 4773–4775.CrossRefGoogle Scholar
  18. 18.
    Nie, Z.; Xu, S.; Seo, M.; Lewis, P. C.; Kumacheva, E. J. Am. Chem. Soc. 2005, 127, 8058–8063.CrossRefGoogle Scholar
  19. 19.
    Champion, J. A.; Katare, Y. K.; Mitragotri, S. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (29), 11901–11904CrossRefGoogle Scholar
  20. 20.
    Chang, Z.; Serra, C.; Bouquey, M.; Prat, L.; Hadziioannou, G. Lab. Chip. 2009, 9, 3007–3011.CrossRefGoogle Scholar
  21. 21.
    Serra, C.; Berton, N.; Bouquey, M.; Prat, L.; Hadziioannou, G. Langmuir 2007, 23 (14), 7745–7750.CrossRefGoogle Scholar
  22. 22.
    Ohm, C.; Serra, C.; Zentel, R. Adv. Mater. 2009, 21, 4859–4862.CrossRefGoogle Scholar
  23. 23.
    Ohm, C.; Serra, C.; Kraus, I.; Zentel, R. Adv. Funct. Mater. 2010, 20, 4314–4322.CrossRefGoogle Scholar
  24. 24.
    Chang, Z.; Serra, C. A.; Bouquey, M.; Kraus, I.; Li, S.; Köhler, J. M. Nanotechnology 2010, 21 (1), 015605.CrossRefGoogle Scholar
  25. 25.
    Knauer, A.; Csáki, A.; Fritzsche, W.; Serra, C. A.; Leclerc, N.; Köhler, J. M. Chem. Eng. J. 2013, 227, 191–197.CrossRefGoogle Scholar
  26. 26.
    Koehler, J. M.; Maerz, A.; Popp, J.; Knauer, A.; Kraus, I.; Faerber, J.; Serra, C. Anal. Chem. 2013, 85 (1), 313–318.CrossRefGoogle Scholar
  27. 27.
    Khan, I. U.; Serra, C. A.; Anton, N.; Vandamme, T. Int. J. Pharm. 2013, 441 (1–2), 809–817.CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó 2013

Authors and Affiliations

  • Christophe A. Serra
    • 1
  • Ikram U. Khan
    • 1
    • 2
    • 3
  • ZhenQi Chang
    • 1
  • Michel Bouquey
    • 1
  • René Muller
    • 1
  • Isabelle Kraus
    • 4
  • Marc Schmutz
    • 5
  • Thierry Vandamme
    • 2
  • Nicolas Anton
    • 2
  • Christian Ohm
    • 6
  • Rudolf Zentel
    • 6
  • Andrea Knauer
    • 7
  • Michael Köhler
    • 7
  1. 1.Groupe d’Intensification et d’Intégration des Procédés Polymères (G2IP), Institut de Chimie et Procédés pour l’Énergie, l’Environnement et la Santé (ICPEES) — UMR 7515 CNRS, École Européenne de Chimie, Polymères et Matériaux (ECPM)Université de Strasbourg (UdS)StrasbourgFrance
  2. 2.Equipe de Pharmacie Biogalénique, Laboratoire de Conception et Application de Molécules Bioactives — CNRS 7199, Faculté de PharmacieUniversité de Strasbourg (UdS)Illkirch CedexFrance
  3. 3.College of PharmacyGovernment College UniversityFaisalabadPakistan
  4. 4.Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), UMR 7504CNRS - Université de StrasbourgStrasbourgFrance
  5. 5.Centre National de la Recherche ScientifiqueInstitut Charles Sadron (ICS), UPR 22StrasbourgFrance
  6. 6.Institute of Organic Chemistry, and Excellence Graduate School MAINZUniversity of MainzMainzGermany
  7. 7.Department of Physical Chemistry and Microreaction TechnologyInstitute of Physics, Technical University of IlmenauIlmenauGermany

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