Journal of Flow Chemistry

, Volume 2, Issue 2, pp 63–68 | Cite as

Highlights from the Flow Chemistry Literature 2012 (Part 1)

  • Toma N. Glasnov
Research Highlights


In this section of the journal, the continuous flow chemistry literature of the preceding months is presented. Included are articles published in January and February 2012 and some articles from 2011 which received page numbers only in the beginning of 2012. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end.

Further Flow Chemistry Publications

  1. “Transesterification of rapeseed oil under flow conditions catalyzed by basic solids: M—Al(La)—O (M=Sr, Ba), M—Mg—O (M=Y, La)” O. V. Sherstyuk, A. S. Ivanova, M. Y. Lebedev, M. V. Bukhtiyarova, L. G. Matvienko, A. A. Budneva, A. N. Simonov, V. A. Yakovlev Applied Catalysis A: General 2011, 419–420, 73–83Google Scholar
  2. “Meter-long and robust supramolecular strands encapsulated in hydrogel jackets” D. Kiriya, M. Ikeda, H. Onoe, M. Takinoue, H. Komatsu, Y. Shimoyama, I. Hamachi, S. Takeuchi Angewandte Chemie International Edition 2012, 51, 1553–1557CrossRefGoogle Scholar
  3. “Continuous-flow synthesis of the anti-malaria drug artemisinin” F. Levesque, P. H. Seeberger Angewandte Chemie International Edition 2012, 51, 1706–1709CrossRefGoogle Scholar
  4. “Towards quantitative conversion of microalgae oil to diesel-range alkanes with bifunctional catalysts” B. Peng, Y. Yao, C. Zhao, J. A. Lercher Angewandte Chemie International Edition 2012, 51, 2072–2075CrossRefGoogle Scholar
  5. “Triphase microfluidic-directed self-assembly: Anisotropic colloidal photonic crystal supraparticles and multicolor patterns made easy” Z. Yu, C.-F. Wang, L. Ling, L. Chen, S. Chen Angewandte Chemie International Edition 2012, 51, 2375–2378CrossRefGoogle Scholar
  6. “Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis” M. Rueping, T. Bootwicha, E. Sugiono Beilstein Journal of Organic Chemistry 2012, 8, 300–307CrossRefGoogle Scholar
  7. “Microfluidic technology: An economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET)” V. Bouvet, M. Wuest, P.-H. Tam, M. Wang, F. Wuest Bioorganic & Medicinal Chemistry Letters 2012, 22, 2291–2295CrossRefGoogle Scholar
  8. “Modified zeolite ZSM-5 for the methanol to aromatics reaction” M. Conte, J. A. Lopez-Sanchez, Q. He, D. J. Morgan, Y. Ryabenkova, J. K. Bartley, A. F. Carley, S. H. Taylor, C. J. Kiely, K. Khalid, J. Hutchings Catalysis Science & Technology 2012, 2, 105–112CrossRefGoogle Scholar
  9. “Aqueous phase Fischer-Tropsch synthesis in a continuous flow reactor” L. Liu, G. Sun, C. Wang, J. Yang, C. Xiao, H. Wang, D. Ma, Y. Kou Catalysis Today 2012, 183, 136–142CrossRefGoogle Scholar
  10. “Continuous flow synthesis of conjugated polymers” H. Seyler, D. J. Jones, A. B. Holmes, W. W. H. Wong Chemical Communications 2012, 48, 1598–1600CrossRefGoogle Scholar
  11. “Continuous flow metal-free oxidation of picolines using air” M. Hamano, Kevin D. Nagyz, K. F. Jensen Chemical Communications 2012, 48, 2086–2088CrossRefGoogle Scholar
  12. “Maximising the efficiency of continuous photo-oxidation with singlet oxygen in supercritical CO2 by use of fluorous biphasic catalysis” J. F. B. Hall, X. Han, M. Poliakoff, R. A. Bourne, M. W. George Chemical Communications 2012, 48, 3073–3075CrossRefGoogle Scholar
  13. “Continuous flow photocatalytic oxidation of nitrogen oxides over anodized nanotubular titania films” G. Kontos, A. Katsanaki, V. Likodimos, T. Maggos, D. Kim, C. Vasilakos, D. D. Dionysiou, P. Schmuki, P. Falaras Chemical Engineering Journal 2012, 179, 151–157CrossRefGoogle Scholar
  14. “Heterogeneously catalyzed synthesis of performic acid in a microstructured reactor” F. Ebrahimi, E. Kolehmainen, I. Turunen Chemical Engineering Journal 2012, 179, 312–317CrossRefGoogle Scholar
  15. “Multiphase minireactor system for direct fluorination of ethylene carbonate” P. Langa, M. Hill, I. Krossing, P. Woias Chemical Engineering Journal 2012, 179, 330–337CrossRefGoogle Scholar
  16. “Direct carbonylation of nitrobenzene to phenylisocyanate using gas-liquid slug flow in microchannel” Y. Takebayashi, K. Sue, S. Yoda, T. Furuya, K. Mae Chemical Engineering Journal 2012, 180, 250–254CrossRefGoogle Scholar
  17. “Controllable synthesis of microscale titania fibers and tubes using colaminar microflows” W. Lan, S. Li, J. Xu, G. Luo Chemical Engineering Journal 2012, 181–182, 828–833CrossRefGoogle Scholar
  18. “Design of optimal multiphase reactors exemplified on the hydroformylation of long chain alkenes” A. Peschel, B. Hentschel, H. Freund, K. Sundmacher Chemical Engineering Journal 2012, 188, 126–141CrossRefGoogle Scholar
  19. “Monitoring on-chip Pictet-Spengler reactions by integrated analytical separation and label-free time-resolved fluorescence” S. Ohla, R. Beyreiss, S. Fritzsche, P. Glaser, S. Nagl, K. Stockhausen, C. Schneider, D. Belder Chemistry — A European Journal 2012, 18, 1240–1246CrossRefGoogle Scholar
  20. “Gas-liquid segmented flow microfluidics for screening Pd-catalyzed carbonylation reactions” X. Gong, P. W. Miller, A. D. Gee, N. J. Long, A. J. de Mello, R. Vilar Chemistry — A European Journal 2012, 18, 2768–2772CrossRefGoogle Scholar
  21. “Biodiesel process intensification in a very simple microchannel device” E. Santacesaria, M. Di Serio, R. Tesser, R. Turco, M. Tortorelli, V. Russo Chemical Engineering and Processing: Process Intensification 2012, 52, 47–54CrossRefGoogle Scholar
  22. “Hydrodeoxygenation of pyrolysis oil in a microreactor” N. Joshi, A. Lawal Chemical Engineering Science 2012, 74, 1–8CrossRefGoogle Scholar
  23. “Design and operation of a filter reactor for continuous production of a selected pharmaceutical intermediate” K. M. Christensen, M. J. Pedersen, K. Dam-Johansen, T. L. Holm, T. Skovby, S. Kiil Chemical Engineering Science 2012, 71, 111–117CrossRefGoogle Scholar
  24. “Sequential immobilization of enzymes in microfluidic channels for cascade reactions” S. Fornera, P. Kuhn, D. Lombardi, A. D. Schlüter, P. S. Dittrich, P. Walde ChemPlusChem 2012, 77, 98–101CrossRefGoogle Scholar
  25. “Ritter reactions in flow” L. Audiger, K. Watts, S. C. Elmore, R. I. Robinson, T. Wirth ChemSusChem 2012, 5, 257–260CrossRefGoogle Scholar
  26. “Organocatalyzed epoxidation of alkenes in continuous flow using a multi-jet oscillating disk reactor” R. Spaccini, L. Liguori, C. Punta, H.-R. Bjorsvik ChemSusChem 2012, 5, 261–265CrossRefGoogle Scholar
  27. “Highly efficient 1,4-addition of aldehydes to nitroolefins: Organocatalysis in continuous flow by solid-supported peptidic catalysts” S. B. Ötvös, I. M. Mandity, F. Fülöp ChemSusChem 2012, 5, 266–269CrossRefGoogle Scholar
  28. “Room-temperature, acid-catalyzed [2+2] cycloadditions: Suppression of side reactions by using a flow microreactor system” K. Kurahashi, Y. Takemoto, K. Takasu ChemSusChem 2012, 5, 270–273CrossRefGoogle Scholar
  29. “The oxygen-mediated synthesis of 1,3-butadiynes in continuous flow: Using Teflon AF-2400 to effect gas/liquid contact” T. P. Petersen, A. Polyzos, M. O’Brien, T. Ulven, I. R. Baxendale, S. V. Ley ChemSusChem 2012, 5, 274–277CrossRefGoogle Scholar
  30. “Prilezhaev dihydroxylation of olefins in a continuous flow process” A. M. W. van den Broek, R. Becker, F. Kossl, M. M. E. Delville, P. J. Nieuwland, K. Koch, F. P. J. T. Rutjes ChemSusChem 2012, 5, 289–292CrossRefGoogle Scholar
  31. “Transfer of the epoxidation of soybean oil from batch to flow chemistry guided by cost and environmental issues” D. Kralisch, I. Streckmann, D. Ott, U. Krtschil, E. Santacesaria, M. Di Serio, V. Russo, L. De Carlo, W. Linhart, E. Christian, B. Cortese, M. H. J. M. de Croon, V. Hessel ChemSusChem 2012, 5, 300–311CrossRefGoogle Scholar
  32. “Sequential continuous flow processes for the oxidation of amines and azides by using HOFMeCN” B. McPake, C. B. Murray, G. Sandford ChemSusChem 2012, 5, 312–319CrossRefGoogle Scholar
  33. “TEMPO-mediated electrooxidation of primary and secondary alcohols in a microfluidic electrolytic cell” J. T. Hill-Cousins, J. Kuleshova, R. A. Green, P. R. Birkin, D. Pletcher, T. J. Underwood, S. G. Leach, R. C. D. Brown ChemSusChem 2012, 5, 326–331CrossRefGoogle Scholar
  34. “Solid-supported gallium triflate: An efficient catalyst for the three-component ketonic Strecker reaction” C. Wiles, Paul Watts ChemSusChem 2012, 5, 332–338CrossRefGoogle Scholar
  35. “Practical synthesis of photochromic diarylethenes in integrated flow microreactor systems” T. Asai, A. Takata, A. Nagaki, J.-i. Yoshida ChemSusChem 2012, 5, 339–350CrossRefGoogle Scholar
  36. “Stereocontrolled synthesis of the cis-hydroxydecalin system: Towards biologically active 19-nor-clerodanes” P. M. Mirzayans, R. H. Pouwer, C. M. Williams, P. V. Bernhardt European Journal of Organic Chemistry 2012, 1633–1638Google Scholar
  37. “β-Galactosidase-immobilised microreactor fabricated using a novel technique for enzyme immobilisation and its application for continuous synthesis of lactulose” Y. S. Song, H. Y. Shin, J. Y. Lee, C. Park, S. W. Kim Food Chemistry 2012, 133, 611–617CrossRefGoogle Scholar
  38. “E-factor minimized protocols for the polystyryl-BEMP catalyzed conjugate additions of various nucleophiles to α,β-unsaturated carbonyl compounds” S. Bonollo, D. Lanari, J. M. Longo, L. Vaccaro Green Chemistry 2012, 14, 164–169CrossRefGoogle Scholar
  39. “Catalysis in flow: Au-catalysed alkylation of amines by alcohols” N. Zotova, F. J. Roberts, G. H. Kelsall, A. S. Jessiman, K. Hellgardt, K. K. (Mimi) Hii Green Chemistry 2012, 14, 26–232CrossRefGoogle Scholar
  40. “In situ electrogeneration of o-benzoquinone and high yield reaction with benzenethiols in a microflow system” T. Kashiwagi, F. Amemiya, T. Fuchigami, M. Atobe Green Chemistry 2012, 48, 2806–2808Google Scholar
  41. “Continuous stream processing: A prototype magnetic field induced flow mixer” P. Koos, D. L. Browne, S. V. Ley Green Processing and Synthesis 2012, 1, 11–18CrossRefGoogle Scholar
  42. “Liquid-liquid flow in a capillary microreactor: Hydrodynamic flow patterns and extraction performance” J. Jovanovic, E. V. Rebrov, T. A. (Xander) Nijhuis, M. T. Kreutzer, V. Hessel, J. C. Schouten Industrial Engineering Chemistry Research 2012, 51, 1015–1026CrossRefGoogle Scholar
  43. “Continuous production of Cu2ZnSnS4 nanocrystals in a flow reactor” A. Shavel, D. Cadavid, M. Ibanez, A. Carrete, A. Cabot Journal of the American Chemical Society 2012, 134, 1438–1441CrossRefGoogle Scholar
  44. “Microfluidic study of fast gas-liquid reactions” W. Li, K. Liu, R. Simms, J. Greener, D. Jagadeesan, S. Pinto, A. Günther, E. Kumacheva Journal of the American Chemical Society 2012, 134, 3127–3132CrossRefGoogle Scholar
  45. “Alumina-grafted macro-/mesoporous silica monoliths as continuous flow microreactors for the Diels—Alder reaction” A. Sachse, V. Hulea, A. Finiels, B. Coq, F. Fajula, A. Galarneau Journal of Catalysis 2012, 287, 62–67CrossRefGoogle Scholar
  46. “Dynamic control of gold nanoparticle morphology in a microchannel flow reactor by glucose reduction in aqueous sodium hydroxide solution” T. Ishizaka, A. Ishigaki, H. Kawanami, A. Suzuki, T. M. Suzuki Journal of Colloid and Interface Science 2012, 367, 135–138CrossRefGoogle Scholar
  47. “Low cost and non-surfactant synthesis of fluorinated alumina modified with magnesium for condensation of aniline to diphenylamine” C. Zheng, X. Sun Journal ofFluorine Chemistry 2012, 135, 373–378CrossRefGoogle Scholar
  48. “Simple enzyme immobilization inside glass tubes for enzymatic cascade reactions” S. Fornera, T. Bauer, A. D. Schlüter, P. Walde Journal of Materials Chemistry 2012, 22, 502–511CrossRefGoogle Scholar
  49. “Preparation of well-dispersed PdAu bimetallic nanoparticles on reduced graphene oxide sheets with excellent electrochemical activity for ethanol oxidation in alkaline media” Z. Huang, H. Zhou, C. Li, F. Zeng, C. Fua, Y. Kuang Journal of Materials Chemistry 2012, 22, 1781–1785CrossRefGoogle Scholar
  50. “Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor” K. Kumar, A. M. Nightingale, S. H. Krishnadasan, N. Kamaly, M. Wylenzinska-Arridge, K. Zeissler, W. R. Branford, E. Ware, A. J. deMello, J. C. deMello Journal of Materials Chemistry 2012, 22, 4704–4708CrossRefGoogle Scholar
  51. “Flash flow pyrolysis: Mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment” D. Cantillo, H. Sheibani, C. O. Kappe Journal of Organic Chemistry 2012, 77, 2463–2473CrossRefGoogle Scholar
  52. “Efficient and continuous monoacylation with superior selectivity of symmetrical diamines in microreactors” R. A. Maurya, P. H. Hoang, D.-P. Kim Lab on a Chip 2012, 12, 65–68CrossRefGoogle Scholar
  53. “Coated gas bubbles for the continuous synthesis of hollow inorganic particles” J. Wan, H. A. Stone Langmuir 2012, 28, 37–41CrossRefGoogle Scholar
  54. “Gas sensing with nano-indium oxides (In2O3) prepared via continuous hydrothermal flow synthesis” S. Elouali, L. G. Bloor, R. Binions, I. P. Parkin, C. J. Carmalt, J. A. Darr Langmuir 2012, 28, 1879–1885CrossRefGoogle Scholar
  55. “Continuous steroid biotransformations in microchannel reactors” M. P. C. Marques, P. Fernandes, J. M. S. Cabral, P. Znidarsic-Plazl, I. Plazl New Biotechnology 2012, 29, 227–234CrossRefGoogle Scholar
  56. “Application of a Burkholderia cepacia lipase immobilized silica monolith microbioreactor to continuous flow kinetic resolution for transesterification of (R,S)-1-phenylethanol” K. Kawakami, M. Ueno, T. Takei, Y. Oda, R. Takahashi Process Biochemistry 2012, 47, 147–150CrossRefGoogle Scholar
  57. “Lipase-catalyzed regioselective acylation of sugar in microreactors” L-H. Du, X.-P. Luo RSC Advances 2012, 2, 2663–2665CrossRefGoogle Scholar
  58. “Scale-up of flow-assisted synthesis of C2-symmetric chiral PyBox ligands” C. Battilocchio, M. Baumann, I. R. Baxendale, M. Biava, M. O. Kitching, S. V. Ley, R. E. Martin, S. A. Ohnmacht, N. D. C. Tappina Synthesis 2012, 44, 635–647Google Scholar
  59. “Highly efficient and convenient Strecker reaction of carbonyl compounds and amines with TMSCN catalyzed by MCM-41 anchored sulfonic acid as a recoverable catalyst” M. G. Dekamin, Z. Mokhtari Tetrahedron 2012, 68, 922–930CrossRefGoogle Scholar
  60. “Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives” L. Lengyel, T. Z. Nagy, G. Sipos, R. Jones, G. Dorman, L. Ürge, F. Darvas Tetrahedron Letters 2012, 53, 738–743CrossRefGoogle Scholar
  61. “High-temperature continuous flow synthesis of 1,3,4-oxadiazoles via N-acylation of 5-substituted tetrazoles” B. Reichart, C. O. Kappe Tetrahedron Letters 2012, 53, 952–955CrossRefGoogle Scholar
  62. “Evaluation of a flow-photochemistry platform for the synthesis of compact modules” M. Nettekoven, B. Püllmann, R. E. Martin, D. Wechsler Tetrahedron Letters 2012, 53, 1363–1366CrossRefGoogle Scholar
  63. “Flow microreactor synthesis of tricyclic sulfonamides via N-tosylaziridinyllithiums” E. Takizawa, A. Nagaki, J.-i. Yoshida Tetrahedron Letters 2012, 53, 1397–1400CrossRefGoogle Scholar
  64. “Ultrasound-promoted intramolecular direct arylation in a capillary flow microreactor” L. Zhang, M. Geng, P. Teng, D. Zhao, X.i Lu, J.-Xin Li Ultrasonics Sonochemistry 2012, 19, 250–256CrossRefGoogle Scholar


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Copyright information

© Akadémiai Kiadó 2012

Authors and Affiliations

  • Toma N. Glasnov
    • 1
  1. 1.Institute of ChemistryKarl-Franzens-University GrazGrazAustria

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