Abstract
To expand the knowledge base for fundamental organic reactions in continuous flow, the a-bromination of acetophenone was successfully transformed from a known batch procedure to a continuous flow process in 99 % yield through D-optimal optimisation and subsequent scale-up of the validated optimum. Using a preparative scale system, a space-time yield of 0.26 kg/m3/s (comparable literature batch reaction 0.24 kg/m3/s) was achieved under conditions suitable for laboratory and small-scale industrial application where high yield or purity is required, e.g., when expensive substrates are used.
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Becker, R., van den Broek, S.(.A.M.W., Nieuwland, P.J. et al. Optimisation and Scale-up of α-Bromination of Acetophenone in a Continuous Flow Microreactor. J Flow Chem 2, 87–91 (2012). https://doi.org/10.1556/JFC-D-12-00007
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DOI: https://doi.org/10.1556/JFC-D-12-00007