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Generation and Reactions of Vinyllithiums Using Flow Microreactor Systems

Abstract

Vinyllithiums were effectively generated by bromine-lithium exchange reaction of vinyl bromides with one eq of s-BuLi in a flow microreactor system at 0 °C or 20 °C, although two eq of t-BuLi and much lower temperatures are required for a conventional macro batch reaction. Subsequent reactions with various electrophiles in the flow microreactor system gave the corresponding vinyl compounds in good yields.

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Correspondence to Jun-ichi Yoshida.

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Nagaki, A., Takahashi, Y., Yamada, S. et al. Generation and Reactions of Vinyllithiums Using Flow Microreactor Systems. J Flow Chem 2, 70–72 (2012). https://doi.org/10.1556/JFC-D-12-00004

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  • DOI: https://doi.org/10.1556/JFC-D-12-00004

Keywords

  • flow microreactor
  • vinyllithium