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Generation and Reactions of Vinyllithiums Using Flow Microreactor Systems

Journal of Flow Chemistry volume 2, pages 70–72 (2012)Cite this article

Abstract

Vinyllithiums were effectively generated by bromine-lithium exchange reaction of vinyl bromides with one eq of s-BuLi in a flow microreactor system at 0 °C or 20 °C, although two eq of t-BuLi and much lower temperatures are required for a conventional macro batch reaction. Subsequent reactions with various electrophiles in the flow microreactor system gave the corresponding vinyl compounds in good yields.

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Authors and Affiliations

  1. Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan

    Aiichiro Nagaki, Yusuke Takahashi, Shigeyuki Yamada, Chika Matsuo, Suguru Haraki, Yuya Moriwaki, Songhee Kim & Jun-ichi Yoshida

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  1. Aiichiro Nagaki
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  2. Yusuke Takahashi
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  3. Shigeyuki Yamada
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  4. Chika Matsuo
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  5. Suguru Haraki
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  6. Yuya Moriwaki
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  7. Songhee Kim
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  8. Jun-ichi Yoshida
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Correspondence to Jun-ichi Yoshida.

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Nagaki, A., Takahashi, Y., Yamada, S. et al. Generation and Reactions of Vinyllithiums Using Flow Microreactor Systems. J Flow Chem 2, 70–72 (2012). https://doi.org/10.1556/JFC-D-12-00004

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  • DOI: https://doi.org/10.1556/JFC-D-12-00004

Keywords

  • flow microreactor
  • vinyllithium