Abstract
The absorption, distribution and elimination of fumonisin B1 (FB1) and its metabolites was investigated in pigs. For the determination of the absorption and biotransformation of FB1, T-cannula were implanted into the distal part of experimental pigs’ ileum and the total urine and faeces moiety was collected during the toxin feeding (45 mg FB1/kg diet, duration: 10 days) and in the subsequent elimination period (10 days). At the end of trial several organs, muscle and fat samples were also collected. The accumulative absorption of fumonisin B1 was 4%. In the chymus, the FB1 conversion to aminopentol (totally hydrolysed FB1; AP1) and partially hydrolysed FB1 (PHFB1) was 1% and 3.9%, respectively. Derivatives of FB1 were mostly accumulated in the liver and kidney, while in negligible concentration could be detected in the muscle and fat samples. In the organs the efficacy of the FB1 to AP1 and PHFB1 conversion was 30% and 20%, respectively. In the faecal content the main hydrolised product was PHFB1 (47%), with 12% of AP1. 1.5% of the FB1 quantity taken up was excreted with the urine, about 35% in hydrolyzed form. Detectable amounts of FB1 and its metabolites were measured in most of the organs, in faeces and urine even 10 days after the feeding of the noncontaminated diet. As a general conclusion, the intestinal microbiota of pigs is able to transform the intact FB1 to a similarly toxic substance (partially hydrolyzed FB1) or to a more toxic metabolite (aminopentol).
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Szabó-Fodor, J., Kametler, L., Pósa, R. et al. Kinetics of fumonisin B1 in pigs and persistence in tissues after ingestion of a diet containing a high fumonisin concentration. CEREAL RESEARCH COMMUNICATIONS 36 (Suppl 6), 331–336 (2008). https://doi.org/10.1556/CRC.36.2008.Suppl.B.32
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DOI: https://doi.org/10.1556/CRC.36.2008.Suppl.B.32