Abstract
Serotonin (5-HT) is known to induce a wide range of short-term and long-term (or delayed) effects. In the present paper we demonstrated that short time-window application of the 5-HT precursor 5-hydroxytryptophan during early cleavage stages results in both irreversible morphological malformation (exogastrulation) and distinct changes in behavior of young animals of the freshwater snail, Lymnaea stagnalis (Mollusca: Gastropoda). Pharmacological and immunocytochemical analysis confirmed that both the increase of intracellular 5-HT level within the cleaved blastomers and activation of membrane 5-HT2-like type receptors are required for the appearence of these phenomena.
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Presented during the 12th ISIN Symposium on Invertebrate Neurobiology, August 31–September 4, 2011, Tihany, Hungary.
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Voronezhskaya, E.E., Khabarova, M.Y., Nezlin, L.P. et al. Delayed Action of Serotonin in Molluscan Development. BIOLOGIA FUTURA 63 (Suppl 2), 210–216 (2012). https://doi.org/10.1556/ABiol.63.2012.Suppl.2.28
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DOI: https://doi.org/10.1556/ABiol.63.2012.Suppl.2.28