Abstract
We investigated involvement of different 5-HT receptors in regulation of ciliary rotation, gliding locomotion and heartbeat of Helisoma embryo at pre- and post-metamorphic stages. Pharmacological analysis suggested that activation of 5-HT1 receptor enhance ciliary rotation but do not affect gliding locomotion. Activation of 5-HT4 receptor depresses both types of locomotion. Before metamorphosis heart contraction is depressed by activation of 5-HT4 and enhanced by activation of 5-HT7 receptor. However, the heart became insensitive to all agonists by hatching. We hypothesized that alterations in affinity or expression of particular 5-HT receptors can underlie the well-coordinated character of serotonin-dependent larval behavior.
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Presented during the 12th ISIN Symposium on Invertebrate Neurobiology, August 31–September 4, 2011, Tihany, Hungary.
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Khabarova, M.Y., Voronezhskaya, E.E. Pharmacological Analysis of Locomotion and Heart Contraction During the Development of Helisoma (Mollusca: Gastropoda). BIOLOGIA FUTURA 63 (Suppl 2), 206–209 (2012). https://doi.org/10.1556/ABiol.63.2012.Suppl.2.27
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DOI: https://doi.org/10.1556/ABiol.63.2012.Suppl.2.27