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Monitoring of Neuroactive Factors Released from a Pattern-Generating Network

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To detect neuroactive factors in biological fluids, we have previously elaborated a moveable biosensor, the preparation of isolated neuron penetrated with recording microelectrode [1]. Here, we report that, in the pond snail, signals emanated from a central pattern generator (CPG) for feeding and detected by such biosensor correspond to long-term changes in motor output of the CPG as recorded from buccal nerves. The results suggest that combined recording from motor nerves, neurons in situ and the neuron-based biosensors may be a useful tool in studies of the mechanisms underlying network organisation.


  1. 1.

    Chistopolsky, I. A., Sakharov, D. A. (2007) An isolated neuron-based biosensor to release of neuroactive substances. Russ. J. Physiol. 93, 1210–1213 (in Russian).

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  2. 2.

    Dyakonova, T. L. (1985) Two types of neurons which differ in plasticity: study of ionic mechanisms. Zhurn. Vyssh. Nerv. Deyat. 35, 552–560 (in Russian).

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  3. 3.

    Rose, R. M., Benjamin, P. R. (1981) Interneuronal control of feeding in the pond snail Lymnaea stagnalis.

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  4. 1.

    Initiation of feeding cycles by a single buccal interneurone. J. Exp. Biol. 92, 187–201.

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Correspondence to I. A. Chistopolsky.

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Chistopolsky, I.A., Vorontsov, D.D. & Sakharov, D.A. Monitoring of Neuroactive Factors Released from a Pattern-Generating Network. BIOLOGIA FUTURA 59, 29–31 (2008).

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  • Neuroethology
  • central pattern generator
  • extrasynaptic space
  • isolated neuron
  • Lymnaea stagnalis