Abstract
Cyclin C is a highly conserved protein that is involved in divergent cellular processes. The exact roles of its isoforms are presently not very well defined and it is possible that there is a functional divergence amongst them. We therefore sought to assess the expression pattern of cyclin C1 and C2 isoforms in various human tissues and in cell cycle by using real-time PCR experiments. Our findings strongly suggest that the C2 isoform may play a presently unexplored and important role in mammalian testis and probably this isoform is the one that is mainly implicated in cell cycle regulation.
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Katona, R.L., Loyer, P., Roby, S.K. et al. Two Isoforms of the Human Cyclin C Gene are Expressed Differentially Suggesting that they May Have Distinct Functions. BIOLOGIA FUTURA 58, 133–137 (2007). https://doi.org/10.1556/ABiol.58.2007.1.12
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DOI: https://doi.org/10.1556/ABiol.58.2007.1.12