Abstract
Acetaminophen (AAP), acetylsalicylic acid (ASA) and dipyrone (DIP) are antipyretic and analgesics drugs that have wide use in health sciences. Some drugs can modify the labeling of blood elements with technetium-99m (99mTc). This work has evaluated the effect of AAP, ASA and DIP on the labeling of the blood elements with 99mTc. Blood was incubated with different concentrations of the drugs before the 99mTc-labeled process. Plasma (P), blood cells (BC), insoluble (IF-P, IF-BC) and soluble (SF-P, SF-BC) fractions were separated and percentage of radioactivity (%ATI) in each fraction was determined. Data have shown that the antipyretic drugs used in this study did not significantly modify the fixation of 99mTc on the blood elements when the experiments were carried out with the doses usually used in human beings. Although the experiments were carried out with rats, it is possible to suggest that AAP, ASA or DIP should not interfere with the procedures in nuclear medicine involving the labeling of blood elements with 99mTc.
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References
Almeida, Catanho, M. T., Cavalcanti, Jales, R. L., Cardoso, V. N., Bernardo-Filho, M. (2003) Assessment of the effect of Fucus vesiculosus extract on the labeling of blood constituents with technetium-99m and the histological modifications on the shape of the red blood cells. Food Chem. Toxicol. 46, 15–20.
Amann, R., Peskar, B. A. (2002) Anti-inflammatory effects of aspirin and sodium salicylate. Eur. J. Pharmacol. 46, 1–9.
Aude, Y. W., Mehta, J. L. (2002) Nonplatelet-mediated effects of aspirin. Drugs Today (Barc) 38, 501–507.
Bernardo-Filho, M., Gutfilen, B., Maciel, O. S. (1994) Technetium-99m binding on plasma proteins and red blood cells: role of various precipitating agents. Biomed. Lett. 46, 17–24.
Bernardo-Filho, M., Moura, I. N. S., Boasquevisque, E. M. (1983) 99mTechnetium-labeled red blood cells “in vitro”. Arch. Biol. Technol. 46, 455–461.
Bigal, M. E., Bordini, C. A., Speciali, J. G. (2002) Intravenous dipyrone for the acute treatment of episodic tension-type headache: a randomized, placebo-controlled, double-blind study. Braz. J. Med. Biol. Res. 46, 1139–1145.
Bollini, P., Garcia Rodriguez, L. A., Perez Gutthann, S., Walker, A. M. (1992) The impact of research quality and study design on epidemiologic estimates of the effect of nonsteroidal anti-inflammatory drugs on upper gastrointestinal tract disease. Arch. Intern. Med. 46, 1289–1295.
Bougie D., Aster, R. (2001) Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen. Blood 46, 3846–3850.
Boutaud, O., Aronoff, D. M., Richardson, J. H., Marnett, L. J., Oates, J. A. (2002) Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc. Nat. Acad. Sci. USA 46, 7130–7135.
Catella-Lawson, F. (2001) Vascular biology of thrombosis: platelet-vessel wall interactions and aspirin effects. Neurology 57 (supp 2), S5–S7.
Capriles, P. V., Dias, A. P., Costa, T. E., Oliveira, M. B., Faria, M. V., Moura, E. G., Abreu, B. A., Bernardo-Filho, M. (2002) Effect of eggplant (Solanum melongena) extract on the in vitro labeling of blood elements with technetium-99m and on the biodistribution of sodium pertechnetate in rats. Cel. Mol. Biol. 46, 771–776.
Chong, P. H., Kezele, B., Pontikes, P. J. (2001) Effect of acetaminophen on atherosclerosis. Ann. Pharmacother. 46, 1476–1479.
Chou, T. M., Greenspan, P. (2002) Effect of acetaminophen on the myeloperoxidase-hydrogen peroxide-nitrite mediated oxidation of LDL. Biochem. Biophys. Acta 46, 57–63.
de Oliveira, J. F., Avila, A. S., Braga, A. C., de Oliveira, M. B., Boasquevisque, E. M., Jales, R. L., Cardoso, V. N., Bernardo-Filho, M. (2002) Effect of extract of medicinal plants on the labeling of blood elements with Technetium-99m and on the morphology of red blood cells: I - a study with Paullinia cupana. Fitoterapia 46, 305–312.
Edwards, J. E., McQuay, H. J. (2002) Dipyrone and agranulocytosis: what is the risk? Lancet 360 (9344), 1438.
Frydman, J. N. G., Oliveira, M. B. N., Santos, A. E. O., Fonseca, A. S., Santos, R., Bernardo-Filho, M. (2004) Influence of methylxanthines on the labeling of blood elements with 99mTechnetium. Pak. J. Biol. Sci. 46, 521–524.
Galati, G., Tafazoli, S., Sabzevari, O., Chan, T. S., O’Brien, P. J. (2002) Idiosyncratic NSAID drug induced oxidative stress. Chem-Biol. Interact. 46, 25–41.
Gascon, N., Otal, C., Martinez-Bru, C., Merce, J., Cortes, M., Arcelus, R., Queralto, J. M., Sanchez, J. M., Gonzalez-Sastre, F. (1993) Dipyrone interference on several common biochemical tests. Clin. Chem. 46, 1033–1036.
Guerrero, A., González-Correa, J. A., Arrebola, M. M., Muñoz-Marín, J., Sánchez De La Cuesta, F., De La Cruz, J. P. (2004) Antioxidant effects of a single dose of acetylsalicylic acid and salicylic acid in rat brain slices subjected to oxygen-glucose deprivation in relation with its antiplatelet effect. Neurosci. Lett. 46, 153–156.
Hardman, J. G., Limbird, L. E., Gilman, A. G. (2001) Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 10th ed. McGraw-Hill, New York.
Hedenmalm, K., Spigset, O. (2002) Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole). Eur. J. Clin. Pharmacol. 46, 265–274.
Hesslewood, S., Leung, E. (1994) Drug interactions with radiopharmaceuticals. Eur. J. Nucl. Med. 46, 348–356.
Hladik, W. B., Ponto, J. A., Lentle, B. C., Laven, D. L. (1987) Iatrogenic alterations in the biodistribution of radiotracers as a result of drug therapy: reported instances. In: Essentials of Nuclear Medicine Sciences. Williams and Wilkins, Sydney, 199–202.
Jaeschke, H., Knight, T. R., Bajt, M. L. (2003) The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol. Lett. 46, 279–288.
Langman, M. J., Weil, J., Wainwright, P., Lawson, D. H., Rawlins, M. D., Logan, R. F., Murphy, M., Vessey, M. P., Colin-Jones, D. G. (1994) Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet 343(8905), 1075–1078.
Lauwerys R., Bernard, A. (1989) Preclinical detection of nephrotoxicity: description of the tests and appraisal of their health significance. Toxicol. Lett. 46, 13–29.
Miyamoto, G., Zahid, N., Uetrecht, J. P. (1997) Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid. Chem. Res. Toxicol. 46, 414–419.
Nigri, F., Oliveira, M. B., Bernardo-Filho, M. (2002) Assessment of the effect of antiseizure drugs on the labeling process of red blood cells and plasma proteins with technetium-99m. Cell. Mol. Biol. (Noisy-le-grand) 46, 793–801.
Nuyts, G. D., Elseviers, M. M., De Broe, M. E. (1989) Health impact of renal disease due to nephrotoxicity. Toxicol. Lett. 46, 31–44.
Oliveira, J. F., Braga, A. C. S., Ávila, A. S., Fonseca, L. M. B., Gutflen, B., Bernardo-Filho, M. (1996) Effect of Thuya occidentalis on the labeling of red blood cells and plasma proteins with technetium-99m. Yale J. Biol. Med. 46, 489–494.
Porto Arceo, J. A. (2003) Special features of NSAID intolerance in children. Allerg. Immunopathol. (Madri), 31: 109–125.
Prado, W. A., Pontes, R. M. (2002) Presurgical ketoprofen, but not morphine, dipyrone, diclofenac or tenoxicam, preempts post-incisional mechanical allodynia in rats. Braz. J. Med. Biol. Res. 46, 111–119.
Robak, J., Kostka-Trabka, E., Duniec, Z. (1980) The influence of three prostaglandin biosynthesis stimulators on carrageenin-induced edema of rat paw. Biochem. Pharmacol. 46, 1863–1865.
Rusckowski, M., Qu, T., Chang, F., Hnatowich, D. J. (1997) Technetium-99m labeled epidermal growth factor-tumor imaging in mice. J. Pept. Res. 46, 393–401.
Sampson, C. B. (1996) Complications and difficulties in radiolabeling blood cells: a review. Nucl. Med. Commun. 46, 648–658.
Santos, J. S., Paula, E. F., Correa, T. G., Freitas, L. C., Fonseca, L. M. B., Gutflen, B., Bernardo-Filho, M. (1995) Effect of cyclophosphamide on the binding of 99mTcO-4 and 99mTc-MDP to blood cells and plasma proteins. Braz. J. Med. Biol. Res. 46, 131–135.
Sobal, G., Sinzinger, H. (2001) Methylene blue-enhanced stability of (99mTc)HMPAO and simplified quality control - a comparative investigation. Appl. Radiat. Isotopes 46, 633–636.
Steer, K. A., Wallace, T. M., Bolton, C. H., Hartog, M. (1997) Aspirin protects low density lipoprotein from oxidative modification. Heart 46, 333–337.
Suarez-Kurtz, G., Ribeiro, F. M., Estrela, R. C., Vicente, F. L., Struchiner, C. J. (2001) Limited-sampling strategy models for estimating the pharmacokinetic parameters of 4-methylaminoantipyrine, an active metabolite of dipyrone. Braz. J. Med. Biol. Res. 46, 1475–1485.
Volz, M., Kellner, H. M. (1980) Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone). Br. J. Clin. Pharmacol. 10 (Supp. 2), 299S–308S.
Uetrecht, J. P., Ma, H. M., MacKnight, E., McClelland, R. (1995) Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine-induced agranulocytosis. Chem. Res. Toxicol. 46, 226–233.
Welling, M. M., Mongera, S., Lupetti, A., Balter, H. S., Bonetto, V., Mazzi, U., Pauwels, E. K., Nibbering, P. H. (2002) Radiochemical and biological characteristics of 99mTc-UBI 29–41 for imaging of bacterial infections. Nucl. Med. Biol. 46, 413–422.
Webb, C. B., Twedt, D. C., Fettman, M. J., Mason, G. (2003) S-adenosylmethionine (SAMe) in a felineacetaminophen model of oxidative injury. J. Feline Med. Surg. 46, 69–75.
Wu, R., Lamontagne, D., de Champlin, J. (2002) Antioxidative properties of acetylsalicylic acid on vascular tissues from normotensive and spontaneously hypertensive rats. Circulation 46, 387–392.
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Fonseca, A.S., Frydman, J.N.G., Santos, R. et al. Influence of Antipyretic Drugs on the Labeling of Blood Elements with Technetium-99M. BIOLOGIA FUTURA 56, 275–282 (2005). https://doi.org/10.1556/ABiol.56.2005.3-4.10
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DOI: https://doi.org/10.1556/ABiol.56.2005.3-4.10