Abstract
The aim of the present study was to identify molecules that may be involved in neuron-microglia communication in the CNS of freshwater snail Planorbarius corneus. Messenger molecules are exchanged in normal and pathological conditions and we tried to identify some of them by immunocytochemistry on whole ganglia and cell cultures. In particular, we examined neurons and microglia for the expression of some cytokines, IL-1α, IL-1β, IL-6 and TNF-and the neurotransmitter glutamate. These substances may be released by suffering or injured neurons and communicate to microglia the damaging event. Even microglia, on own turn, once activated, express and released the same or other substances in order to rerestablish the system homeostasis, depending on modalities and times of activation. We discuss the possibility that hyperactivated microglia can shift from neuroprotective to neurodegenerative. Moreover, we examined in neuron-microglia co-coltures the direct interaction effects in terms of neuronal survival and improved neurite regeneration.
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Presented at the 10th ISIN Symposium on Invertebrate Neurobiology, July 5–9, 2003, Tihany, Hungary.
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Sonetti, D., Peruzzi, E. Neuron-Microglia Communication in the CNS of the Freshwater Snail Planorbarius Corneus. BIOLOGIA FUTURA 55, 273–285 (2004). https://doi.org/10.1556/ABiol.55.2004.1-4.33
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DOI: https://doi.org/10.1556/ABiol.55.2004.1-4.33