Abstract
We describe octopamine responses of 3 large buccal neurons of Lymnaea and test the hypothesis that these are cAMP-dependent.
The B1 neuron is excited by octopamine and the depolarisation is significantly enlarged (P < 0.05) by application of the blocker of cAMP breakdown, 3-isobutyl-l-methylxanthine (IBMX). The Bl neuron is also depolarised by forskolin, an activator of adenylyl cyclase.
The B2 and B3 neurons are inhibited by octopamine, and the response is not affected by IBMX. Both cells are excited by forskolin.
We conclude that the Bl neuron response to octopamine is likely to be mediated by cAMP, while the B2 and B3 responses are cAMP-independent.
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Presented at the 10th ISIN Symposium on Invertebrate Neurobiology, July 1–5, 2003, Tihany, Hungary.
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Pitt, S., Vehovszky, Á., Szabó, H. et al. Second Messengers of Octopamine Receptors in the Snail Lymnaea. BIOLOGIA FUTURA 55, 177–183 (2004). https://doi.org/10.1556/ABiol.55.2004.1-4.22
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DOI: https://doi.org/10.1556/ABiol.55.2004.1-4.22