Abstract
Nausea is an unpleasant sensation usually referred to the stomach and sometimes followed by vomiting. Little is known about the subjective aspects of nausea because like pain and fatigue, it is a private sensation. We conceive of nausea as a complex control mechanism that signals us when not to eat. Our research in the areas of motion sickness and chemotherapy has led us to propose that we each have a dynamic threshold for nausea, which depends on the interaction of inherent factors and more changeable psychological factors, and that this threshold effects the individual’s cognitive appraisal of both the nauseogenic stimulus and his/her bodily change in response to the nauseogenic stimulus. Inherent factors that are described are age, gender and race; psychological factors that are included are anxiety, expectation, anticipation and adaptation. The physiological responses that have been found to accompany nausea include an increase in sympathetic nervous system activity, a decrease in parasympathetic activity, an increase of abnormal dysrhythmic gastric activity, and an increase in plasma vasopressin. It is concluded that beneficial selective reduction of nausea will depend on a greater knowledge of the interaction of the psychological and physiological variables.
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References
Andrykowski, M. A. (1990) The role of anxiety in the development of anticipatory nausea in cancer chemotherapy: A review and synthesis. Psychosom. Med. 52, 458–475.
Edwards, C., Carmichael, J., Baylis, P., Harris, A. (1989) Arginine vasopressin–a mediator of chemotherapy induced emesis. Brit. J. Cancer 59, 467.
Eversmann, T., Gottsmann, M., Uhlich, E., Ulbrecht, G., von Werder, K., Scriba, P. C. (1978) Increased secretion of growth hormone, prolactin, antidiuretic hormone, and cortisol induced by the stress of motion sickness. Aviation, Space and Environmental Medicine 49, 53–57.
Feldman, M., Samson, W. K., O’Dorisio, T. M. (1988) Apomorphine-induced nausea in humans: Release of vasopressin and pancreatic polypeptide. Gastroenterology 95, 721–726.
Gianaros, P. J., Stern, R. M., Morrow, C. R., Hickok, J. T. (2001) Relationship of gastric myoelectrical and cardiac parasympathetic activity to chemotherapy-induced nausea. J. Psychosom. Res. 50, 263–266.
Gianaros, P. J., Quigley, K. S., Mordkoff, J. T., Stern, R. M. (2001) Gastricmyoelectrical and autonomic cardiac reactivity to laboratory stressors. Psychophysiology 38, 1–11.
Grant, P. J., Hughes, J. R., Dean, H. G., Davies, J. A., Prentice, C. R. M. (1986) Vasopressin and catecholamine secretion during apomorphine-induced nausea mediate acute changes in hemostatic function in man. Clin. Sci. 71, 621–624.
Hawthorn, J., Andrews, P. L. R., Ang, V. T. Y., Jenkins, J. S. (1988) Differential release of vasopressin and oxytocin in response to abdominal vagal afferent stimulation of apomorphine in the ferret. Brain Res. 438, 193–198.
Jacobsen, P. B., Andrykowski, M. A., Redd, W. H., Die- Trill, M., Hakes, T. B., Kaufman, R. J., Currie, V. E., Holland, J. C. (1988) Nonpharmacologic factors in the development of post treatment nausea with adjuvant chemotherapy for breast cancer. Cancer 61, 379–385.
Jokerst, M. D., Gatto, M., Fazio, R., Gianaros, P. J., Stern, R. M., Koch, K. L. (1999) Effects of gender of subjects and experimenter on susceptibility to motion sickness. Aviation, Space and Environmental Medicine 70, 962–965.
Kelly, K. (1993) A neural control of gastric electrical and motor activity. In: Brooks, F. P., Evers, P. W. (eds). Nerves and the Gut. Slack, Thorofare, New Jersey.
Kirsch, I. (1999). How Expectancies Shape Experience. American Psychological Association, Washington, D.C. pp. 5–8.
Koch, K. L., Stern, R. M., Vasey, M. W., Seaton, J. F., Demers, L. M., Harrison, T. S. (1990) Neuroendocrine and gastric myoelectric responses to illusory self-motion in men. Am. J. Physiol. 258, E304–E310.
Levine, M. E., Stern, R. M. (2002) The effect of placebo-induced expectations on gastric tachyarrhythmia and vection-induced nausea. Neurogastroenterology and Motility. 14, 319.
Marten, P. A., Brown, T. A., Barlow, D. H., Borkovec, T. D., Shear, K. M., Lydiard, R. B. (1993) Evaluation of the ratings comprising the associated symptom criterion of DSM-III-R Generalized Anxiety Disorder. J. Nervous & Mental Disorders 181, 676–682.
Morrow, G. R. (1989) Chemotherapy-related nausea and vomiting: Etiology and management. Cancer 39, 89–104.
Reason, J. T., Brand, J. J. (1975). Motion Sickness. Academic Press, London.
Robertson, G. L. (1977) The regulation of vasopressin function in health and disease. Recent Progr. Hormonal Res. 33, 333–385.
Stern, R. M., Koch, K. L., Muth, E. R. (2000) Gastrointestinal System. In: Cacioppo, J. T., Tassinary, L. G., Berntson, G. G. (eds). Handbook of Psychophysiology, 2nd ed. Cambridge University Press, Cambridge, pp.
Stern, R. M., Koch, K. L. (1996) Motion sickness and differential susceptibility. Curr. Directions Psycholog. Sci. 5, 115–120.
Stern, R. M., Hu, S., LeBlanc, R., Koch, K. L. (1993) Chinese hyper-susceptibility to vection-induced motion sickness. Aviation, Space and Environmental Medicine 64, 827–830.
Stern, R. M., Hu, S., Uijtdehaage, S. H. J., Muth, E. R., Xu, L. H., Koch, K. L. (1996) Asian hypersusceptibility to motion sickness. Human Heredity 46, 7–14.
Stern, R. M., Hu, S., Vasey, M. W., Koch, K. L. (1989) Adaptation to vection-induced symptoms of motion sickness. Aviation, Space, and Environmental Medicine 60, 566–571.
Verbalis, J. G., Richardson, D. W., Stricker, E. M. (1987) Vasopressin release in response to nauseaproducing agents and cholecystokinin in monkeys. Am. J. Physiol. 252, 749–753.
Xu, L. H., Koch, K. L., Summy- Long, J., Stern, R. M., Seaton, J. F., Harrison, T. S., Demers, L. M., Bingaman, S. (1993) Hypothalamic and gastric myoelectric responses during vection-induced nausea in healthy Chinese subjects. Am. J. Physiol. 265, E578–E584.
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Dedicated to Professor György Ádám on the occasion of his 80th birthday.
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Stern, R.M. The Psychophysiology of Nausea. BIOLOGIA FUTURA 53, 589–599 (2002). https://doi.org/10.1556/ABiol.53.2002.4.17
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DOI: https://doi.org/10.1556/ABiol.53.2002.4.17