Abstract
Infectious complications are still the leading cause of morbidity and mortality in seriously ill patients [1–3]. To combat the resistance of (mainly Gram-negative, non-fermentative) bacteria, e.g. Pseudomonas aeruginosa, to a wide spectrum of antibiotics, drug combination therapy has been widely adopted as standard clinical practice since the late 1990s. β-Lactam combinations are not optimal and the potential of nephrotoxicity and ototoxicity from aminoglycosides has caused clinicians to evaluate new possibilities, such as combinations of fluoroquinolones and β-lactams. We examine here the synergic and post-antibiotic effects (PAEs) of ciprofloxacin, ofloxacin and pefloxacin-ceftazidime combinations against 6 clinical Pseudomonas isolates.
The fluoroquinolone-ceftazidime combinations were not only synergic against Comamonas (P.) testosteroni, but had double the PAEs of the two drugs alone. The ciprofloxacin-ceftazidime combination had a longer PAE against P. aeruginosa isolate 1 than ciprofloxacin alone. The combinations, however, did not have longer PAEs than those of the single drugs against the other 5 P. aeruginosa isolates.
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Dedicated to Professor Lajos Ferenczy on the occasion of his 70th birthday.
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Mayer, I., Nagy, E. Post-Antibiotic and Synergic Effects of Fluoroquinolones and Ceftazidime in Combination Against Pseudomonas Strains. BIOLOGIA FUTURA 52, 241–248 (2001). https://doi.org/10.1556/ABiol.52.2001.2-3.8
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DOI: https://doi.org/10.1556/ABiol.52.2001.2-3.8