Abstract
Optimizing current chemical processes alone does not yield the improvements required in the fine chemical and pharmaceutical industries. At least partially, a switch from batch to continuous manufacturing is needed. Cost-, time-, and atom-efficient routes frequently demand the application of high temperatures, pressures, and concentrations, and/or the use of highly reactive reagents. These chemistries often cannot be employed in conventional reactors. Costly and long alternative synthetic routes are chosen instead. The application of continuous-flow microreactors allows to access “harsh” or “hazardous” reaction conditions and, furthermore, enables entirely new transformations.
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Gutmann, B., Kappe, C.O. Forbidden Chemistries — Paths to a Sustainable Future Engaging Continuous Processing. J Flow Chem 7, 65–71 (2017). https://doi.org/10.1556/1846.2017.00009
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DOI: https://doi.org/10.1556/1846.2017.00009