Abstract
In this Section of the journal, the literature on continuous flow synthesis (primarily organic synthesis and functional materials) from the period of July–September 2016 is presented. All the publications are listed ordered by journal name, with 8 Review articles appearing at the end. In this quarter the number of papers on continuous flow organic synthesis is relatively more and with a few special issues planned in the coming months this number will increase significantly. There are many ‘firsts’ achieved in flow synthesis in the last quarter, but the most noticeable ones include the synthesis of Water-Stable Covalent Organic Frameworks and flow synthesis using in-situ generated chlorine!
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“Toward the Synthesis of Noroxymorphone via Aerobic Palladium-Catalyzed Continuous Flow N-Demethylation Strategies” Gutmann, B.; Elsner, P.; Cox, D. P.; Weigl, U.; Roberge, D. M.; Kappe, C. O. ACS Sustainable Chemistry & Engineering 2016, 4, 6048–6061
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“A Sustainable, Semi-Continuous Flow Synthesis of Hydantoins” Vukelic, S.; Koksch, B.; Seeberger, P. H.; Gilmore, K. Chemistry - A European Journal 2016, 22, 13451–13454
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“Continuous UV-Flow Microsystem for Efficient Radical Generation from Organotrifluoroborates by Photoredox Catalysis” El Achi, N.; Penhoat, M.; Bakkour, Y.; Rolando, C.; Chausset-Boissarie, L. European Journal of Organic Chemistry 2016, 4284–4288
“Anionic Flow Polymerizations toward Functional Polyphosphoesters in Microreactors: Polymerization and UV-Modification” Baeten, E.; Vanslambrouck, S.; Jérôme, C.; Lecomte, P.; Junkers, T. European Polymer Journal 2016, 80, 208–218
“Flow Synthesis of Medium Molecular Weight Polyisobutylene Coinitiated by AlCl3” Zhu, S.; Lu, Y.; Wang, K.; Luo, G. European Polymer Journal 2016, 80, 219–226
“From Alcohol to 1,2,3-Triazole via A Multi-Step Continuous-Flow Synthesis of a Rufinamide Precursor” Borukhova, S.; Noel, T.; Metten, B.; de Vos, E.; Hessel, V. Green Chemistry 2016, 18, 4947–4953
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“On the Fly Multi-Modal Observation of Ligand Synthesis and Complexation of Cu Complexes in Flow with ’Benchtop’ NMR and Mass Spectrometry” Porwol, L.; Henson, A.; Kitson, P. J.; Long, D.-L.; Cronin, L. Inorganic Chemistry Frontiers 2016, 3, 919–923
“Effects of Heterogeneous-Homogeneous Interaction on the Homogeneous Ignition in Hydrogen-Fueled Catalytic Microreactors” Chen, J.; Liu, B.; Gao, X.; Yan, L.; Xu, D. International Journal of Hydrogen Energy 2016, 41, 11441–11454
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“Direct Aldol and Nitroaldol Condensation in an Aminosilane-Grafted Si/Zr/Ti Composite Hollow Fiber as a Heterogeneous Catalyst and Continuous-Flow Reactor” He, Y.; Jawad, A.; Li, X.; Atanga, M.; Rezaei, F.; Rownaghi, A. A. Journal of Catalysis 2016, 341, 149–159
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“Protected Diazonium Salts: A Continuous-Flow Preparation of Triazenes Including the Anticancer Compounds Dacarbazine and Mitozolomide” Schotten, C.; Aldmairi, A. H.; Sagatov, Y.; Shepherd, M.; Browne, D. L. Journal of Flow Chemistry 2016, 6, 218–225
“Delivering Enhanced Efficiency in the Synthesis of a-Diazosulfoxides by Exploiting the Process Control Enabled in Flow” McCaw, P. G.; Deadman, B. J.; Maguire, A. R.; Collins, S. G. Journal of Flow Chemistry 2016, 6, 226–233
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“Fischer Indole Reaction in Batch and Flow Employing a Sulfonic Acid Resin: Synthesis of Pyrido[2,3-a]Carbazoles” Bosch, C.; López-Lledó, P.; Bonjoch, J.; Bradshaw, B.; Nieuwland, P. J.; Blanco-Ania, D.; Rutjes, F. P. J. T. Journal of Flow Chemistry 2016, 6, 240–243
“Continuous Suzuki—Miyaura Reactions with Novel Ce—Sn—Pd Oxides and Integrated Crystallization as Continuous Downstream Protocol” Lichtenegger, G. J.; Maier, M.; Khinast, J. G.; Gruber-Wölfler, H. Journal of Flow Chemistry 2016, 6, 244–251
“Photo-Claisen Rearrangement of Allyl Phenyl Ether in Microflow: Influence of Phenyl Core Substituents and Vision on Orthogonality” Shahbazali, E.; Noël, T.; Hessel, V. Journal of Flow Chemistry 2016, 6, 252–259
“Photo-Induced Copper-Mediated Acrylate Polymerization in Continuous-Flow Reactors” Railian, S.; Wenn, B.; Junkers, T. Journal of Flow Chemistry 2016, 6, 260–267
“Microreactor Mixing-Unit Design for Fast Liquid—Liquid Reactions” Mielke, E.; Roberge, D. M.; Macchi, A. Journal of Flow Chemistry 2016, 6, 279–287
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“Catalytic Macrocyclization Strategies Using Continuous Flow: Formal Total Synthesis of Ivorenolide A” de Léséleuc, M.; Godin, É.; Parisien-Collette, S.; Lévesque, A.; Collins, S. K. Journal of Organic Chemistry 2016, 81, 6750–6756
“Synthesis of a-Nitro Carbonyls via Nitrations in Flow” Chentsova, A.; Ushakov, D. B.; Seeberger, P. H.; Gilmore, K. Journal of Organic Chemistry 2016, 81, 9415–9421
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“Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s” Hafner, A.; Meisenbach, M.; Sedelmeier, J. Organic Letters 2016, 18, 3630–3633
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“A Small-Footprint, High-Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale” Elliott, L. D.; Berry, M.; Haiji, B.; Klauber, D.; Leonard, J.; Booker-Milburn, K. I. Organic Process Research & Development 2016, 20, 1806–1811
“Ultra-Fast Continuous-Flow Photo Degradation of Organic Peroxide Explosives for Their Efficient Conversion into Hydrogen Peroxide and Possible Application” Mahbub, P.; Wilson, R.; Nesterenko, P. N. Propellants, Explosives, Pyrotechnics 2016, 41, 757–763
“Self-Optimisation of the Final Stage in the Synthesis of EGFR Kinase Inhibitor AZD9291 Using an Automated Flow Reactor” Holmes, N.; Akien, G. R.; Blacker, A. J.; Woodward, R. L.; Meadows, R. E.; Bourne, R. A. Reaction Chemistry & Engineering 2016, 1, 366–371
“Continuous Flow Synthesis of the Iodination Agent 1,3-Diiodo-5,5-Dimethyl-Imidazolidine-2,4-Dione Telescoped with Semi-Continuous Product Isolation” Ferreri, M.; Drageset, A.; Gambarotti, C.; Bjorsvik, H.-R. Reaction Chemistry & Engineering 2016, 1, 379–386
“Continuous Flow Synthesis Concatenated with Continuous Flow Liquid-Liquid Extraction for Work-up and Purification: Selective Mono- and Di-Iodination of the Imidazole Backbone” Drageset, A.; Bjorsvik, H.-R. Reaction Chemistry & Engineering 2016, 1, 436–444
“A Laboratory-Scale Continuous Flow Chlorine Generator for Organic Synthesis” Strauss, F. J.; Cantillo, D.; Guerra, J.; Kappe, C. O. Reaction Chemistry & Engineering 2016, 1, 472–476
“An Approach to the Synthesis of 4-Aryl and 5-Aryl Substituted Thiazole-2(3H)-Thiones Employing Flow Processing” Balti, M.; Miller, S. A.; Efrit, M. L.; Leadbeater, N. E. RSC Advances 2016, 6, 72165–72169
“Synthesis of Unsaturated Secondary Amines by Direct Reductive Amination of Aliphatic Aldehydes with Nitroarenes over Au/Al2O3 Catalyst in Continuous Flow Mode” Nuzhdin, A. L.; Artiukha, E. A.; Bukhtiyarova, G. A.; Zaytsev, S. Y.; Plyusnin, P. E.; Shubin, Y. V.; Bukhtiyarov, V. I. RSC Advances 2016, 6, 88366–88372
“A Two-Step Continuous Flow Synthesis of 1,4-Disubstituted 1,2,3-Triazoles under Metal- and Azide-Free Conditions” Gu, J.; Fang, Z.; Yang, Z.; Li, X.; Zhu, N.; Wan, L.; Wei, P.; Guo, K. RSC Advances 2016, 6, 89073–89079
“Temperature Distribution Monitoring of a Coiled Flow Channel in Microwave Heating Using an Optical Fiber Sensing Technique” Wada, D.; Sugiyama, J.-i.; Zushi, H.; Murayama, H. Sensors and Actuators B: Chemical 2016, 232, 434–441
“Biodiesel Synthesis Using Integrated Acid and Base Catalysis in Continuous Flow” Asadi, M.; Hooper, J. F.; Lupton, D. W. Tetrahedron 2016, 72, 3729–3733
Nanomaterials
“High-Throughput Synthesis of Lignin Particles (~30 nm to ~2 p.m) via Aerosol Flow Reactor: Size Fractionation and Utilization in Pickering Emulsions” Ago, M.; Huan, S.; Borghei, M.; Raula, J.; Kauppinen, E. I.; Rojas, O. J. ACS Applied Materials & Interfaces 2016, 8, 23302–23310
“Controllable Synthesis of Gold Nanoparticles in Aqueous Solution by Microwave Assisted Flow Chemistry” Bayazit, M. K.; Yue, J.; Cao, E.; Gavriilidis, A.; Tang, J. ACS Sustainable Chemistry & Engineering 2016, 4, 6435–6442
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“Room Temperature Batch and Continuous Flow Synthesis of Water-Stable Covalent Organic Frameworks (COFs)” Peng, Y.; Wong, W. K.; Hu, Z.; Cheng, Y.; Yuan, D.; Khan, S. A.; Zhao, D. Chemistry of Materials 2016, 28, 5095–5101
“Synthesis of Ultra-Small Platinum Nanoparticles in a Continuous Flow Microreactor” Suryawanshi, P. L.; Gumfekar, S. P.; Kumar, P. R.; Kale, B. B.; Sonawane, S. H. Colloid and Interface Science Communications 2016, 13, 6–9
“Microfluidic Assisted Synthesis of Silver Nanoparticle-Chitosan Composite Microparticles for Antibacterial Applications” Yang, C.-H.; Wang, L.-S.; Chen, S.-Y.; Huang, M.-C.; Li, Y.-H.; Lin, Y.-C.; Chen, P.-F.; Shaw, J.-F.; Huang, K.-S. International Journal of Pharmaceutics 2016, 510, 493–500
“Synthesis of Silver Nanoparticles Using a Microfluidic Impinging Jet Reactor” Baber, R.; Mazzei, L.; Thanh, N. T. K.; Gavriilidis, A. Journal of Flow Chemistry 2016, 6, 268–278
“Co-Flow Microfluidic Synthesis of Liquid Crystalline Actuating Janus Particles” Hessberger, T.; Braun, L. B.; Henrich, F.; Muller, C.; Serra, C.; Zentel, R. Journal of Materials Chemistry C 2016, 4, 8778–8786
“Ionic Self-Assembly of a Giant Vesicle as a Smart Microcarrier and Microreactor” Shen, J.; Xin, X.; Liu, T.; Wang, S.; Yang, Y.; Luan, X.; Xu, G.; Yuan, S. Langmuir 2016, 6, 9548–9556
“Monolithic Hierarchical Gold Sponges for Efficient and Stable Catalysis in a Continuous-Flow Microreactor” Yu, Y.; Xiao, W.; Zhou, T.; Zhang, P.; Yan, C.; Zheng, Z. Materials Chemistry Frontiers 2016, doi: 10.1039/C6QM00115G
“Titania-Silica Monolithic Multichannel Microreactors. Proof of Concept and Fabrication/Structure/Catalytic Properties in the Oxidation of 2,3,6-Trimethylphenol” Koreniuk, A.; Maresz, K.; Odrozek, K.; Mrowiec-Bialon, J. Microporous and Mesoporous Materials 2016, 229, 98–105
Reviews
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“Flow Technology for Organometallic-Mediated Synthesis” Degennaro, L.; Carlucci, C.; De Angelis, S.; Luisi, R. Journal of Flow Chemistry 2016, 6, 136–166
“Concepts and Optimization Strategies of Experimental Design in Continuous-Flow Processing” Gioiello, A.; Mancino, V.; Filipponi, P.; Mostarda, S.; Cerra, B. Journal of Flow Chemistry 2016, 6, 167–180
“Separation Units and Equipment for Lab-Scale Process Development” Hohmann, L.; Kurt, S. K.; Soboll, S.; Kockmann, N. Journal of Flow Chemistry 2016, 6, 181–190
“Electrosynthesis in Extended Channel Length Microfluidic Electrolysis Cells” Green, R. A.; Brown, R. C. D.; Pletcher, D. Journal of Flow Chemistry 2016, 6, 191–197
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“Reaction Screening in Continuous Flow Reactors” Mohamed, D. K. B.; Yu, X.; Li, J.; Wu, J. Tetrahedron Letters 2016, 57, 3965–3977
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Kulkarni, A.A. Highlights from the Flow Chemistry Literature 2016 (Part 3). J Flow Chem 6, 323–328 (2016). https://doi.org/10.1556/1846.2016.44444
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DOI: https://doi.org/10.1556/1846.2016.44444