Abstract
The Sandmeyer reaction of anilines to generate aryl azides, followed by the Ru(porphyrin)CO-catalyzed addition to styrenes affording N-aryl aziridines was successfully performed for the first time in mesoreactors, under continuousflow conditions. Mesofluidic technology allowed for a rapid screening of different parameters and a quick identification of the optimized reaction conditions for the two separate steps. The two optimized reactions were then combined in a single continuous process that allowed a safe and efficient synthesis of N-arylaziridines from convenient commercially available starting materials.
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Rossi, S., Puglisi, A., Intrieri, D. et al. From Anilines to Aziridines: A Two-Step Synthesis under Continuous-Flow Conditions. J Flow Chem 6, 234–239 (2016). https://doi.org/10.1556/1846.2016.00027
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DOI: https://doi.org/10.1556/1846.2016.00027