Abstract
An efficient and metal-free method for the oxidation of aldehydes to the corresponding carboxylic acids has been developed. In a simple continuous-flow photochemical reactor, the use of camphorquinone (CQ) irradiated with a white light-emitting diode (LED) source enhanced the autoxidation of aldehydes. Under 5 bar of oxygen, visible light, and 0.3 mol% of CQ, the rate of oxidation was increased from 6 times with 2-ethylhexanal to 30 times for n-nonanal. The large interfacial area generated by a segmented flow apparatus associated with radicals formed by photooxidation of CQ ensures metal-free high throughput of carboxylic acids under safe conditions.
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Hamami, Z.E., Vanoye, L., Fongarland, P. et al. Metal-Free, Visible Light-Promoted Aerobic Aldehydes Oxidation. J Flow Chem 6, 206–210 (2016). https://doi.org/10.1556/1846.2016.00023
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DOI: https://doi.org/10.1556/1846.2016.00023