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A Microfluidic Toolbox for the Development of In-Situ Product Removal Strategies in Biocatalysis

Journal of Flow Chemistry volume 6, pages 18–26 (2016)Cite this article

Abstract

A microfluidic toolbox for accelerated development of biocatalytic processes has great potential. This is especially the case for the development of advanced biocatalytic process concepts, where reactors and product separation methods are closely linked together to intensify the process performance, e.g., by the use of in-situ product removal (ISPR). This review provides a general overview of currently available tools in a microfluidic toolbox and how this toolbox can be applied to the development of advanced biocatalytic process concepts. Emphasis is placed on describing the possibilities and advantages of the microfluidic toolbox that are difficult to achieve with conventional batch-processbased technologies. Application of this microfluidic toolbox will potentially make it possible to intensify biocatalytic reactions and thereby facilitate the development towards novel and advanced biocatalytic processes, which in many cases have proven too difficult in conventional batch equipment.

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Authors and Affiliations

  1. CAPEC-PROCESS Research Center, Department of Chemical and Biochemical Engineering, Technical University of Denmark, Building 229, 2800 Kgs., Lyngby, Denmark

    Søren Heintz, Aleksandar Mitic, Rolf H. Ringborg, Ulrich Krühne, John M. Woodley & Krist V. Gernaey

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  1. Søren Heintz
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  2. Aleksandar Mitic
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  6. Krist V. Gernaey
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Correspondence to Krist V. Gernaey.

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Heintz, S., Mitic, A., Ringborg, R.H. et al. A Microfluidic Toolbox for the Development of In-Situ Product Removal Strategies in Biocatalysis. J Flow Chem 6, 18–26 (2016). https://doi.org/10.1556/1846.2015.00040

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Keyword

  • microfluidics
  • in-situ product removal (ISPR)
  • process intensification
  • biocatalysis
  • process development