Acta Biologica Hungarica

, Volume 64, Issue 2, pp 249–261 | Cite as

Synthesis and Different Biological Activities of Novel Benzoxazoles

  • O. Temiz-ArpaciEmail author
  • B. Eylem Cifcioglu Goztepe
  • Fatma Kaynak-Onurdag
  • Selda Ozgen
  • Fatma Sezer Senol
  • I. Erdogan Orhan


A series of 2-[4-(4-substitutedbenzamido/phenylacetamido/butanamido)phenyl]-5-ethylsulphonyl-benzoxazole derivatives were synthesized and biologically evaluated as possible antimicrobial agents and inhibitors of tyrosinase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). The results demonstrated that the synthesized compounds exhibited a broad spectrum of activity with minimum inhibitory concentration (MIC) values of 128-16 µg/ml against some Gram-positive, Gram-negative bacteria as well as Candida albicans and C. krusei. The compound 10 displayed higher activity in this series against methicilline resistant Staphylococcus aureus (MRSA) with a MIC value of 16 µg/ml than the compared control drugs ampicillin and ceftriaxone. Compound 14 showed moderate tyrosinase inhibition, however, none of the compounds showed effect as inhibitor of AChE and BChE.


Benzoxazoles antibacterial activity antifungal activity enzyme inhibition synthesis 


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© Akadémiai Kiadó, Budapest 2013

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • O. Temiz-Arpaci
    • 1
    Email author
  • B. Eylem Cifcioglu Goztepe
    • 1
  • Fatma Kaynak-Onurdag
    • 2
  • Selda Ozgen
    • 2
  • Fatma Sezer Senol
    • 3
  • I. Erdogan Orhan
    • 3
    • 4
  1. 1.Department of Pharmaceutical Chemistry, Faculty of PharmacyAnkara UniversityTandogan, AnkaraTurkey
  2. 2.Department of Microbiology, Faculty of PharmacyGazi UniversityEtiler, AnkaraTurkey
  3. 3.Department of Pharmacognosy, Faculty of PharmacyGazi UniversityEtiler, AnkaraTurkey
  4. 4.Pharmacognosy Unit, Faculty of PharmacyEastern Mediterranean UniversityGazimagosa, The Northern CyprusTurkey

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