Synthesis and Different Biological Activities of Novel Benzoxazoles


A series of 2-[4-(4-substitutedbenzamido/phenylacetamido/butanamido)phenyl]-5-ethylsulphonyl-benzoxazole derivatives were synthesized and biologically evaluated as possible antimicrobial agents and inhibitors of tyrosinase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). The results demonstrated that the synthesized compounds exhibited a broad spectrum of activity with minimum inhibitory concentration (MIC) values of 128-16 µg/ml against some Gram-positive, Gram-negative bacteria as well as Candida albicans and C. krusei. The compound 10 displayed higher activity in this series against methicilline resistant Staphylococcus aureus (MRSA) with a MIC value of 16 µg/ml than the compared control drugs ampicillin and ceftriaxone. Compound 14 showed moderate tyrosinase inhibition, however, none of the compounds showed effect as inhibitor of AChE and BChE.


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Temiz-Arpaci, O., Goztepe, B.E.C., Kaynak-Onurdag, F. et al. Synthesis and Different Biological Activities of Novel Benzoxazoles. BIOLOGIA FUTURA 64, 249–261 (2013).

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  • Benzoxazoles
  • antibacterial activity
  • antifungal activity
  • enzyme inhibition
  • synthesis