Serotonin Transport and Synthesis Systems During Early Development of Invertebrates: Functional Analysis on a Bivalve Model

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Serotonin (5.HT) is known to be functionally active during early development in both vertebrates and invertebrates. However, the presence of 5-HT and its synthesis and transport system has not yet been demonstrated in bivalve early development. The presence of 5-HT was immunochemically demonstrated at the cleavage stage of bivalve Mytilus trossulus. 5-HT level dramatically increased within all embryonic cells after incubation with 5-HTP but not after incubation with tryptophan and 5-HT. The first 5-HT uptake by specific transporter was detected at 13 hpf blastula stage only and it was restricted to one distinct cell.


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Correspondence to E. G. Ivashkin.

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Presented during the 12th ISIN Symposium on Invertebrate Neurobiology, August 31–September 4, 2011, Tihany, Hungary.

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Ivashkin, E.G., Khabarova, M.Y. & Voronezhskaya, E.E. Serotonin Transport and Synthesis Systems During Early Development of Invertebrates: Functional Analysis on a Bivalve Model. BIOLOGIA FUTURA 63, 217–220 (2012).

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  • Serotonin
  • SERT
  • Mytilus trossulus
  • Mollusca
  • cleavage
  • blastula