Acta Biologica Hungarica

, Volume 63, Supplement 2, pp 206–209 | Cite as

Pharmacological Analysis of Locomotion and Heart Contraction During the Development of Helisoma (Mollusca: Gastropoda)

Short Communication
  • Marina Yu. Khabarova
  • Elena E. VoronezhskayaEmail author
Open Access


We investigated involvement of different 5-HT receptors in regulation of ciliary rotation, gliding locomotion and heartbeat of Helisoma embryo at pre- and post-metamorphic stages. Pharmacological analysis suggested that activation of 5-HT1 receptor enhance ciliary rotation but do not affect gliding locomotion. Activation of 5-HT4 receptor depresses both types of locomotion. Before metamorphosis heart contraction is depressed by activation of 5-HT4 and enhanced by activation of 5-HT7 receptor. However, the heart became insensitive to all agonists by hatching. We hypothesized that alterations in affinity or expression of particular 5-HT receptors can underlie the well-coordinated character of serotonin-dependent larval behavior.


5-HT agonists ciliary rotation gliding locomotion heartbeat 


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Copyright information

© Akadémiai Kiadó, Budapest 2012

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Marina Yu. Khabarova
    • 1
  • Elena E. Voronezhskaya
    • 1
    Email author
  1. 1.Department of Comparative PhysiologyInstitute of Developmental Biology RASMoscowRussia

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