Toxic Nuclear Effects of the Organophosphorus Insecticide Dichlorvos (DDVP) in Human Peripheral Blood Lymphocytes

Abstract

Organophosphorus insecticides are used worldwide in the control of agricultural, household and veterinary pests. Dichlorvos (2,2-dichlorovinyl dimethyl phosphate) is a commonly used organophosphorus insecticide. In this study, in order to elucidate the toxic nuclear effects of dichlorvos, freshly isolated human peripheral blood lymphocytes were incubated with 5, 10, 20, 40, 80 and 100 μg/mL of dichlorvos. According to the results, dichlorvos induced micronuclei, decreased the mitotic and replication indexes. It is a genotoxic product causing chromosomal damage (an increase in micronucleus) and cell death (decrease in mitotic and replication indexes).

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Acknowledgement

The author wishes to thank Miss. Emine Ölmez for sending blood samples used in this study.

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Correspondence to H. E. Eroğlu.

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Eroğlu, H.E. Toxic Nuclear Effects of the Organophosphorus Insecticide Dichlorvos (DDVP) in Human Peripheral Blood Lymphocytes. BIOLOGIA FUTURA 60, 409–416 (2009). https://doi.org/10.1556/ABiol.60.2009.4.7

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Keywords

  • Dichlorvos
  • toxicity
  • micronucleus
  • mitotic index
  • replication index