Monitoring of Neuroactive Factors Released from a Pattern-Generating Network
To detect neuroactive factors in biological fluids, we have previously elaborated a moveable biosensor, the preparation of isolated neuron penetrated with recording microelectrode . Here, we report that, in the pond snail, signals emanated from a central pattern generator (CPG) for feeding and detected by such biosensor correspond to long-term changes in motor output of the CPG as recorded from buccal nerves. The results suggest that combined recording from motor nerves, neurons in situ and the neuron-based biosensors may be a useful tool in studies of the mechanisms underlying network organisation.
KeywordsNeuroethology central pattern generator extrasynaptic space isolated neuron Lymnaea stagnalis
Unable to display preview. Download preview PDF.
- 1.Chistopolsky, I. A., Sakharov, D. A. (2007) An isolated neuron-based biosensor to release of neuroactive substances. Russ. J. Physiol. 93, 1210–1213 (in Russian).Google Scholar
- 2.Dyakonova, T. L. (1985) Two types of neurons which differ in plasticity: study of ionic mechanisms. Zhurn. Vyssh. Nerv. Deyat. 35, 552–560 (in Russian).Google Scholar
- 3.Rose, R. M., Benjamin, P. R. (1981) Interneuronal control of feeding in the pond snail Lymnaea stagnalis.Google Scholar
- 1.Initiation of feeding cycles by a single buccal interneurone. J. Exp. Biol. 92, 187–201.Google Scholar
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.