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Acta Biologica Hungarica

, Volume 59, Supplement 2, pp 189–197 | Cite as

The Actions of Caenorhabditis elegans Neuropeptide-Like Peptides (NLPs) on Body Wall Muscle of Ascaris suum and Pharyngeal Muscle of C. elegans

  • Sylvana Papaioannou
  • Lindy Holden-Dye
  • R. J. WalkerEmail author
Article

Abstract

The actions of six Neuropeptide-like Peptides (NLPs) were investigated on Ascaris suum dorsal body wall muscle and Caenorhabditis elegans pharyngeal muscle. The NLPs tested on A. suum muscle, viz, NLP-1A, NLP-2A and B, had no direct effect on the muscle but all reversibly reduced acetylcholine (ACh)-induced contractions of the muscle, NLP-2A being the most potent, with an IC50 value of 78 μM. NLP-2A also reversibly reduced ACh-induced depolarizations of A. suum muscle resting membrane potential. NLP-1A, NLP-2A, NLP-3C and NLP-10A all increased pharyngeal pumping in C. elegans, NLP-8A weakly inhibited pumping while NLP-2B was inactive. NLP-10A induced a concentrationdependent increase in pumping activity with a threshold of 10–100 nM. Since genes encoding NLPs (nlp genes) are expressed in C. elegans pharyngeal neurons it is likely these peptides play a role in feeding behaviour.

Keywords

Ascaris suum Caenorhabditis elegans neuropeptide-like peptides pharynx body wall muscle 

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© Akadémiai Kiadó, Budapest 2008

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Sylvana Papaioannou
    • 1
  • Lindy Holden-Dye
    • 1
  • R. J. Walker
    • 1
    Email author
  1. 1.School of Biological SciencesUniversity of SouthamptonSouthamptonUK

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