Acta Biologica Hungarica

, Volume 59, Supplement 2, pp 189–197 | Cite as

The Actions of Caenorhabditis elegans Neuropeptide-Like Peptides (NLPs) on Body Wall Muscle of Ascaris suum and Pharyngeal Muscle of C. elegans

  • Sylvana Papaioannou
  • Lindy Holden-Dye
  • R. J. WalkerEmail author


The actions of six Neuropeptide-like Peptides (NLPs) were investigated on Ascaris suum dorsal body wall muscle and Caenorhabditis elegans pharyngeal muscle. The NLPs tested on A. suum muscle, viz, NLP-1A, NLP-2A and B, had no direct effect on the muscle but all reversibly reduced acetylcholine (ACh)-induced contractions of the muscle, NLP-2A being the most potent, with an IC50 value of 78 μM. NLP-2A also reversibly reduced ACh-induced depolarizations of A. suum muscle resting membrane potential. NLP-1A, NLP-2A, NLP-3C and NLP-10A all increased pharyngeal pumping in C. elegans, NLP-8A weakly inhibited pumping while NLP-2B was inactive. NLP-10A induced a concentrationdependent increase in pumping activity with a threshold of 10–100 nM. Since genes encoding NLPs (nlp genes) are expressed in C. elegans pharyngeal neurons it is likely these peptides play a role in feeding behaviour.


Ascaris suum Caenorhabditis elegans neuropeptide-like peptides pharynx body wall muscle 


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© Akadémiai Kiadó, Budapest 2008

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Sylvana Papaioannou
    • 1
  • Lindy Holden-Dye
    • 1
  • R. J. Walker
    • 1
    Email author
  1. 1.School of Biological SciencesUniversity of SouthamptonSouthamptonUK

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