Adult-to-Embryo Chemical Signaling in the Regulation of Larval Development in Trochophore Animals: Cellular and Molecular Mechanisms


The regulation of larval development by starved adults occurs in both freshwater snails, Helisoma trivolvis and marine polychaetes, Platynereis dumerilii. Serotonin (5-HT) links this environmental signal which is detected by larval apical sensory neurons to changes in larval development. A profile of the stage-dependent expression of 5-HT receptors and coupled G proteins is essential in this regulatory mechanism. The final effect on development depends on the modulation of the activity of the larval digestive system.


  1. 1.

    Beklemishev, V. N. (1964) Principles of Comparative Anatomy of Invertebrates. Moscow: Nauka.

    Google Scholar 

  2. 2.

    Burke, R. D. (1984) Pheromonal control of metamorphosis in the pacific sand dollar, Dendraster excentricus. Science. 225, 442–443.

    CAS  Article  Google Scholar 

  3. 3.

    Ivanova-Kazas, O. M. (1995) Evolutionary Embryology of Animals. St. Peterburg: Nauka.

    Google Scholar 

  4. 4.

    Mescheriakov, V. N. (1990) The common pond snail Lymnaea stagnalis L. In: Dettlaff, D. A., Vassetzky, S. G. (eds) Animal Species for Developmental Studies. New York, NY: Plenum Press, pp. 69–132.

    Chapter  Google Scholar 

  5. 5.

    Nielsen, C. (2001) Animal Evolution: Interrelationships of the Living Phyla, 2nd edn. Oxford., UK: Oxford University Press.

    Google Scholar 

  6. 6.

    Pawlik, J. R. (1992) Chemical ecology of the settlement of benthic marine invertebrates. Oceanogr. Mar. Biol. Annu. Rev. 30, 273–335.

    Google Scholar 

  7. 7.

    Thomas, J. H. (1993) Chemosensory regulation of development in C. elegans. Bioessays 15, 791–797.

    CAS  Article  Google Scholar 

  8. 8.

    Voronezhskaya, E. E., Khabarova, M. Yu., Nezlin L. P. (2004) Apical sensory neurones mediate developmental retardation induced by conspecific environmental stimuli in freshwater pulmonate snails. Development. 131, 3671–3680.

    CAS  Article  Google Scholar 

  9. 9.

    Voronezhskaya, E. E., Khabarova, M. Yu., Chaban, A. K., Nezlin, L. P. (2007) Role of chemical signalling in release of motor programs during embryogenesis of freshwater snails Lymnaea stagnalis and Helisoma trivolvis. Rus. J. Developm. Biol. 38, 66–75.

    CAS  Article  Google Scholar 

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Correspondence to Elena E. Voronezhskaya.

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Voronezhskaya, E.E., Glebov, K.I., Khabarova, M.Y. et al. Adult-to-Embryo Chemical Signaling in the Regulation of Larval Development in Trochophore Animals: Cellular and Molecular Mechanisms. BIOLOGIA FUTURA 59, 117–122 (2008).

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  • Serotonin receptors
  • chemical signaling
  • larval
  • developmental regulation
  • Trochozoa