Acta Biologica Hungarica

, Volume 59, Supplement 2, pp 97–100 | Cite as

Relationship Between Developmental Synaptic Modulation and Conditioning-Induced Synaptic Change in Lymnaea

Short Communication
  • T. Karasawa
  • Nao Sato
  • T. Horikoshi
  • M. SakakibaraEmail author


Though adult Lymnaea are bimodal breathers, young animals breathe mainly through the skin and adults through the lung. Operant conditioning changes adult breathing behavior from aerial to cutaneous. We hypothesized that this behavioral change is caused by alterations in the neuronal circuit during both development and conditioning. We focused our study on whether the synaptic connection between RPeD1 and RPA6 neurons is modulated during development and conditioning. Our findings indicated that the RPeD1 has an excitatory monosynaptic contact with the RPA6 in young naïve and operantlyconditioned adult animals. The relationship of this contact was well correlated with their respiratory behavior.


Conditioning synaptic modulation respiratory behavior Lymnaea 


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© Akadémiai Kiadó, Budapest 2008

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • T. Karasawa
    • 1
  • Nao Sato
    • 2
  • T. Horikoshi
    • 2
  • M. Sakakibara
    • 2
    Email author
  1. 1.Course of Biological Science and Technology, Graduate School of High-Technology for Human WelfareTokai UniversityShizuokaJapan
  2. 2.Department of Biological Science and Technology, School of High-Technology for Human WelfareTokai UniversityShizuokaJapan

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