Acta Biologica Hungarica

, Volume 59, Issue 1, pp 93–102 | Cite as

Effects of Polyamines and Polyamine Biosynthetic Inhibitors on Mitotic Activity of Allium Cepa Root Tips

  • Meral Unal
  • Narcin Palavan-Unsal
  • M. A. TufekciEmail author
Open Access


The genotoxic and cytotoxic effects of exogenous polyamines (PAs), putrescine (Put), spermidine (Spd), spermine (Spm) and PA biosynthetic inhibitors, α-difluoromethylornithine (DFMO), cyclohexilamine (CHA), methylglioxal bis-(guanylhydrazone) (MGBG) were investigated in the root meristems of Allium cepa L. The reduction of mitotic index and the induction of chromosomal aberrations such as bridges, stickiness, c-mitotic anaphases, micronuclei, endoredupliction by PAs and PA biosynthetic inhibitors were observed and these were used as evidence of genotoxicity and cytotoxicity.


Allium cepa chromosome aberration mitotic activity polyamine polyamine biosynthetic inhibitor 


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© Akadémiai Kiadó, Budapest 2008

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Meral Unal
    • 1
  • Narcin Palavan-Unsal
    • 2
  • M. A. Tufekci
    • 3
    Email author
  1. 1.Department of Biology, Arts and Sciences FacultyMarmara UniversityIstanbulTurkey
  2. 2.Faculty of Science and LettersIstanbul Kultur UniversityIstanbulTurkey
  3. 3.Department of Molecular Biology and Genetics, Faculty of Arts and SciencesTC Halic UniversityIstanbulTurkey

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