Effects of Polyamines and Polyamine Biosynthetic Inhibitors on Mitotic Activity of Allium Cepa Root Tips


The genotoxic and cytotoxic effects of exogenous polyamines (PAs), putrescine (Put), spermidine (Spd), spermine (Spm) and PA biosynthetic inhibitors, α-difluoromethylornithine (DFMO), cyclohexilamine (CHA), methylglioxal bis-(guanylhydrazone) (MGBG) were investigated in the root meristems of Allium cepa L. The reduction of mitotic index and the induction of chromosomal aberrations such as bridges, stickiness, c-mitotic anaphases, micronuclei, endoredupliction by PAs and PA biosynthetic inhibitors were observed and these were used as evidence of genotoxicity and cytotoxicity.


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Correspondence to M. A. Tufekci.

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Unal, M., Palavan-Unsal, N. & Tufekci, M.A. Effects of Polyamines and Polyamine Biosynthetic Inhibitors on Mitotic Activity of Allium Cepa Root Tips. BIOLOGIA FUTURA 59, 93–102 (2008). https://doi.org/10.1556/ABiol.59.2008.1.8

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  • Allium cepa
  • chromosome aberration
  • mitotic activity
  • polyamine
  • polyamine biosynthetic inhibitor